YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC947.15c
Organism:	Schizosaccharomyces pombe
Length:	551 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC947.15c.

Description	E-value	Query Range	Subject Range
gi\|71062053, gi\|... - gi\|71082940\|ref\|YP_265659.1\| dihydrolipoyl dehydrogenase [Candidatus Pelagibacter ubique HTCC1062], ...	279.0	[0..88]	[542..2]
gi\|91762636, gi\|... - gi\|91762636\|ref\|ZP_01264601.1\| Dihydrolipoyl dehydrogenase [Candidatus Pelagibacter ubique HTCC1002]...	279.0	[0..88]	[542..2]
gi\|49086356, gi\|... - gi\|67517831\|ref\|XP_658698.1\| hypothetical protein AN1094.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	274.0	[0..1]	[550..13]
NDH1_SCHPO - Probable NADH-ubiquinone oxidoreductase C3A11.07, mitochondrial OS=Schizosaccharomyces pombe (strain... SPAC3A11.07 - NADH dehydrogenase	271.0	[0..1]	[551..1]
gi\|25284909 - pir\|\|D83981 pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase) pdhD [imported] - Bacillus ha... gi\|10175273, gi\|... - gi\|15615215\|ref\|NP_243518.1\| dihydrolipoamide dehydrogenase [Bacillus halodurans C-125], gi\|10175273...	271.0	[0..88]	[543..7]
gi\|86135035, gi\|... - gi\|86135035\|ref\|ZP_01053617.1\| dihydrolipoamide dehydrogenase [Polaribacter sp. MED152], gi\|85821898...	266.0	[0..90]	[541..21]
gi\|88713490, gi\|... - gi\|88713490\|ref\|ZP_01107572.1\| Dihydrolipoyl dehydrogenase [Flavobacteriales bacterium HTCC2170], gi...	265.0	[0..88]	[542..1]
gi\|32421857, gi\|... - gi\|32421857\|ref\|XP_331372.1\| hypothetical protein [Neurospora crassa], gi\|28920404\|gb\|EAA29772.1\| hy... gi\|85091656 - gi\|85091656\|ref\|XP_959008.1\| hypothetical protein NCU11397 [Neurospora crassa OR74A]	265.0	[0..1]	[550..16]
gi\|23502768, gi\|... - gi\|23502768\|ref\|NP_698895.1\| dihydrolipoamide dehydrogenase [Brucella suis 1330], gi\|23348787\|gb\|AAN... gi\|254708909 - gi\|254708909\|ref\|ZP_05170720.1\| dihydrolipoamide dehydrogenase [Brucella pinnipedialis B2/94] gi\|254707554 - gi\|254707554\|ref\|ZP_05169382.1\| dihydrolipoamide dehydrogenase [Brucella pinnipedialis M163/99/10] gi\|254700562 - gi\|254700562\|ref\|ZP_05162390.1\| dihydrolipoamide dehydrogenase [Brucella suis bv. 5 str. 513] gi\|225616943, gi... - gi\|225628118\|ref\|ZP_03786153.1\| dihydrolipoamide dehydrogenase [Brucella ceti str. Cudo], gi\|2256169... gi\|254715982 - gi\|254715982\|ref\|ZP_05177793.1\| dihydrolipoamide dehydrogenase [Brucella ceti M13/05/1] gi\|254713664 - gi\|254713664\|ref\|ZP_05175475.1\| dihydrolipoamide dehydrogenase [Brucella ceti M644/93/1]	264.0	[0..91]	[542..3]
gi\|237788347, gi... - gi\|237816280\|ref\|ZP_04595273.1\| dihydrolipoamide dehydrogenase [Brucella abortus str. 2308 A], gi\|23... gi\|254690062 - gi\|254690062\|ref\|ZP_05153316.1\| dihydrolipoamide dehydrogenase [Brucella abortus bv. 6 str. 870] gi\|82700684 - gi\|82700684\|ref\|YP_415258.1\| dihydrolipoamide dehydrogenase [Brucella melitensis biovar Abortus 2308... gi\|82616785 - gi\|82616785\|emb\|CAJ11874.1\| Pyridine nucleotide-disulphide oxidoreductase, class-II:NAD binding site... gi\|62290772, gi\|... - gi\|62290772\|ref\|YP_222565.1\| dihydrolipoamide dehydrogenase [Brucella abortus bv. 1 str. 9-941], gi\|... gi\|254696175 - gi\|254696175\|ref\|ZP_05158003.1\| dihydrolipoamide dehydrogenase [Brucella abortus bv. 2 str. 86/8/59] gi\|254731093 - gi\|254731093\|ref\|ZP_05189671.1\| dihydrolipoamide dehydrogenase [Brucella abortus bv. 4 str. 292] gi\|189020559, gi... - gi\|189024987\|ref\|YP_001935755.1\| dihydrolipoamide dehydrogenase [Brucella abortus S19], gi\|189020559...	264.0	[0..91]	[542..3]

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Predicted Domain #1

Region A:
Residues: [1-87]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSKARLQS VVRLSRTVPY SKTMVRSFHV SCAVKNSGNV PTPRNKSFFS RALEMAEVTS  60
   61 SLSMLGAVAL FQSLRRLNNS SPKGKSG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.69897
Match:	1ps9A
Description:	The Crystal Structure and Reaction Mechanism of E. coli 2,4-Dienoyl CoA Reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [88-551]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPKKNIVVLG SGWGAVAAIK NLDPSLYNIT LVSPRDHFLF TPMLPSCTVG TLRLPSITEP  60
   61 IVALFKGKID PSNIHQAECT AIDTSAKKVT IRGTTEANEG KEAVIPYDTL VFAIGAGNQT 120
  121 FGIQGVRDHG CFLKEAGDAK KVFNRIFEIL EQVRFNKDLS PEERARLLHI TVVGGGPTGM 180
  181 EFAAEMQDFI DNDVKDMFPE LQKDIHVTLI EAAPGVLPMF TKSLITYTEN LFKNLNIKIM 240
  241 TKTVVKDVNE KNLIVQKTNP DGSKAMQEIP YGMLVWAAGI TARPLTRTLM SSIPEQSGAR 300
  301 KGLIVDEFFR VKGVPEMYAV GDCAFSGLPA TAQVANQQGA WLAKNLNVEG KKFALHERIQ 360
  361 ALEKQLGEKE APSQVAGLKQ QVEQLKLEPF KYHHQGALAY VGDEKAIADL KLPFMKKMLP 420
  421 LQGIVGHTFW RLAYLNELIS ARSQFMVLID WLKTRLFGRY DAKV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.522879
Match:	1ebdA
Description:	Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on NADH or NADPH	6.80483427531026	bayes_pls_golite062009
NADH dehydrogenase activity	4.48519830611958	bayes_pls_golite062009
oxidoreductase activity	4.24087829378489	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.23866802882306	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.17680574270434	bayes_pls_golite062009
cation transmembrane transporter activity	2.12428437083016	bayes_pls_golite062009
ion transmembrane transporter activity	2.08195722912776	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.04920820091696	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.9459068794385	bayes_pls_golite062009
substrate-specific transporter activity	1.9173550230784	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	1.6187224316494	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	1.59912481901166	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.45104542724719	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.31328088143083	bayes_pls_golite062009
protein binding	1.16738144711505	bayes_pls_golite062009
binding	0.993436593091194	bayes_pls_golite062009
NADPH-adrenodoxin reductase activity	0.689874846468951	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.36771673037999	bayes_pls_golite062009
glutathione-disulfide reductase activity	0.33334782799369	bayes_pls_golite062009
lipoamide binding	0.193025676337591	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	0.18455498413733	bayes_pls_golite062009
coenzyme binding	0.146916113354806	bayes_pls_golite062009
cofactor binding	0.0578189575854124	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: