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View Structure Prediction Details

Protein: otu1
Organism: Schizosaccharomyces pombe
Length: 329 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for otu1.

Description E-value Query
Range
Subject
Range
gi|109018563 - gi|109018563|ref|XP_001083461.1| PREDICTED: similar to HIV-induced protein-7-like protease [Macaca m...
312.0 [0..5] [328..48]
gi|114572284 - gi|114572284|ref|XP_525042.2| PREDICTED: YOD1 OTU deubiquinating enzyme 1 homolog isoform 2 [Pan tro...
310.0 [0..5] [328..48]
YOD1 - YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)
310.0 [0..5] [328..48]
gi|47169474, gi|... - gi|57114298|ref|NP_001008889.1| YOD1 OTU deubiquinating enzyme 1 homolog [Rattus norvegicus], gi|471...
308.0 [0..5] [328..3]
gi|57089291 - gi|57089291|ref|XP_547387.1| PREDICTED: similar to HIV-induced protein-7-like protease [Canis famili...
307.0 [0..5] [328..45]
gi|26331862, gi|... - gi|30520089|ref|NP_848806.1| HIV-induced protein-7-like protease [Mus musculus], gi|26331862|dbj|BAC...
306.0 [0..5] [328..3]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLRLRLKY ENQSAVETVE ANATVGSFLD LVAAKFSLPR NSIALKFGFP PQDIPLVNSD  60
   61 VPLSTLVSSG QQILVLKNAA TSFSTNEPAK PPIPNAATKP TFPPQTEISN PP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.25
Match: 1ip9A
Description: Bud emergence mediator Bemp1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.21864685713998 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.24290839691082 bayes_pls_golite062009
protein kinase activity 1.16090501968072 bayes_pls_golite062009
kinase activity 1.13491087747775 bayes_pls_golite062009
protein serine/threonine kinase activity 1.02766102100178 bayes_pls_golite062009
protein binding 0.989073783870014 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.931601886287953 bayes_pls_golite062009
transferase activity 0.533092562154647 bayes_pls_golite062009
hydrolase activity 0.383621648094138 bayes_pls_golite062009
catalytic activity 0.202719107986908 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [113-255]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVSHQSKNTS QDPPYVSTPI GDIALRVMPD DNSCLFRALS KPLGFSPYEL REIVANQVLS  60
   61 NPDIYSTAIL GKPSIEYASW IRKETSWGGY IELSILSSHF GVEICSVDVK TGRVDSYNPQ 120
  121 PATGQRTYIV YSGIHYDLAA LAA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.522879
Match: 1tffA
Description: Structure of Otubain-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
peptidase activity 3.28868056127375 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.01472402774099 bayes_pls_golite062009
thiolester hydrolase activity 2.96735553959103 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
hydrolase activity 2.29464693834116 bayes_pls_golite062009
endopeptidase activity 2.26699762664334 bayes_pls_golite062009
transcription regulator activity 2.13534310479552 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
DNA binding 1.95013248594294 bayes_pls_golite062009
binding 1.92046698500094 bayes_pls_golite062009
nucleic acid binding 1.74961503597682 bayes_pls_golite062009
transcription factor activity 1.20242512567523 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.874003454509364 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [256-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLWDTDVDVV LFDASDVTIT PYVQQLASLL KNMHYYTDTA SFSIRCTICG TGLVGEKDAT  60
   61 AHALATGHTQ FGEY

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.3
Match: 1zr9A
Description: Solution Structure of a Human C2H2-type Zinc Finger Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.47951889934838 bayes_pls_golite062009
DNA binding 4.31051339571017 bayes_pls_golite062009
nucleic acid binding 4.04689255235626 bayes_pls_golite062009
transcription factor activity 3.28758716579796 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.05542379535543 bayes_pls_golite062009
transcription activator activity 1.97757778483124 bayes_pls_golite062009
transcription repressor activity 1.44763794968807 bayes_pls_golite062009
sequence-specific DNA binding 1.26862497534835 bayes_pls_golite062009
transcription factor binding 1.23738346570539 bayes_pls_golite062009
chromatin binding 1.10179307236186 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.776754909146767 bayes_pls_golite062009
transcription cofactor activity 0.627794176881836 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009

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Created and Maintained by: Michael Riffle