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View Structure Prediction Details

Protein: pku70
Organism: Schizosaccharomyces pombe
Length: 607 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pku70.

Description E-value Query
Range
Subject
Range
gi|67968771 - gi|67968771|dbj|BAE00743.1| unnamed protein product [Macaca fascicularis]
581.0 [0..9] [605..27]
gi|197101575 - gi|197101575|ref|NP_001126888.1| X-ray repair complementing defective repair in Chinese hamster cell...
gi|55733046 - gi|55733046|emb|CAH93208.1| hypothetical protein [Pongo abelii]
567.0 [0..9] [605..27]
gi|49457432 - gi|49457432|emb|CAG47015.1| G22P1 [Homo sapiens]
565.0 [0..9] [605..27]
gi|19548754, gi|... - gi|74138092|dbj|BAE25441.1| unnamed protein product [Mus musculus], gi|19548756|gb|AAL90775.1| Ku70 ...
562.0 [0..7] [606..23]
gi|149065807, gi... - gi|50927298|gb|AAH78718.1| Xrcc6 protein [Rattus norvegicus], gi|149065807|gb|EDM15680.1| X-ray repa...
559.0 [0..7] [606..23]

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Predicted Domain #1
Region A:
Residues: [1-607]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENDEQIDET ENFAIGKYAI LFVIEVSPSM LDPVDEFTPS SLQMALICAY QLAAQRVITN  60
   61 PSDIMGVLLY GTESSTGRFA NQMMLLDIDP PDAERIKSLQ SFEKDFQFSK EKFKPCSCQV 120
  121 SLSSVLYHCS VIFTTKAENF EKRLFLITDN DHPAWDATER DIILQRAKDL RDLDIQVHPV 180
  181 FLDPPTHSFR INIFYSDFLY IVYGRQDVSN LVNRGQAQLQ HMLNMITALQ KPKRAHFHLK 240
  241 MDLGNDVRIG VEAFILLKRL ESAKTNWVYA KGERFAVAVP QSKQVSFATK KELKKDEIRR 300
  301 SYSYGGSSVV FGSDELNKVR SFEPPTLRII GFRDFSTLKP WHCLKPAVFL RPKDDEIIGS 360
  361 GAVFSAIHKK LLASNKIGIA WFVSRPNANP CFVAMLATPG SIHIRDDFEL PLGIFLVQLP 420
  421 TADDIRSLPP INPNPISMPS NLIETMQRIL RGMELRSYQP GKYNNPSLQW HYKVLQALAL 480
  481 DEEIPTDFVD NTLPKYKAIQ KRVGEYMGDV NNIVAEYRND ISDKNGIKEE EEDQGPIVKK 540
  541 ARIEKSGKPI FAEDDRLKQL YIEGVLDKEI KALKVSQLKD ILRDRGLRVS GKKADLLDNL 600
  601 TNYVKKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 161.0
Match: 1jeqA
Description: DNA binding C-terminal domain of ku70; Ku70 subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
double-stranded telomeric DNA binding 8.64621483095491 bayes_pls_golite062009
telomeric DNA binding 5.16364366157397 bayes_pls_golite062009
transcription regulator activity 3.05720838352689 bayes_pls_golite062009
promoter binding 3.01492777192913 bayes_pls_golite062009
transcription activator activity 2.87080577911324 bayes_pls_golite062009
binding 2.75824485094584 bayes_pls_golite062009
protein binding 2.58357303743968 bayes_pls_golite062009
nucleic acid binding 2.08531850924748 bayes_pls_golite062009
DNA binding 1.91667917801679 bayes_pls_golite062009
transcription factor activity 1.37299910766941 bayes_pls_golite062009
DNA-dependent ATPase activity 0.985753648509262 bayes_pls_golite062009
protein complex binding 0.94234534987624 bayes_pls_golite062009
sequence-specific DNA binding 0.914051610867509 bayes_pls_golite062009
single-stranded DNA binding 0.814975395718076 bayes_pls_golite062009
protein dimerization activity 0.73404855126602 bayes_pls_golite062009
DNA helicase activity 0.720743494912414 bayes_pls_golite062009
protein heterodimerization activity 0.64812784969409 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.506640285146188 bayes_pls_golite062009
structure-specific DNA binding 0.450760554291027 bayes_pls_golite062009
structural molecule activity 0.375125487765613 bayes_pls_golite062009
receptor binding 0.234020194580985 bayes_pls_golite062009
transcription factor binding 0.184852480703492 bayes_pls_golite062009
protein C-terminus binding 0.15516806759612 bayes_pls_golite062009
identical protein binding 0.125363466534611 bayes_pls_golite062009
collagen binding 0.113837148027681 bayes_pls_golite062009
transcription repressor activity 0.0660601071978013 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle