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View Structure Prediction Details

Protein: hem1
Organism: Schizosaccharomyces pombe
Length: 558 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hem1.

Description E-value Query
Range
Subject
Range
HEM0_RAT - 5-aminolevulinate synthase, erythroid-specific, mitochondrial OS=Rattus norvegicus GN=Alas2 PE=1 SV=...
357.0 [0..10] [555..9]
HEM0_DELLE - 5-aminolevulinate synthase, erythroid-specific, mitochondrial OS=Delphinapterus leucas GN=ALAS2 PE=2...
354.0 [0..11] [555..5]
gi|28586 - gi|28586|emb|CAA39795.1| delta-aminolevulinate synthase (erythroid) [Homo sapiens]
354.0 [0..12] [555..6]
HEM0_BOVIN - 5-aminolevulinate synthase, erythroid-specific, mitochondrial OS=Bos taurus GN=ALAS2 PE=2 SV=1
353.0 [0..11] [555..10]
gi|12832778 - gi|12832778|dbj|BAB22254.1| unnamed protein product [Mus musculus]
351.0 [0..10] [555..9]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERVVKLAAK HCPFVSKADP SALRRMAGAG LIRAGARCPV VRHALPVAAA TGADVSRGFK  60
   61 SDSKQMAMEP SLDEIHLKAG VVNTGSRTCR HADAVKAAAE AATTTPVTKK HQMPKHYASD 120
  121 LNGVGPATTP R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [132-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDYDTFYREE LDKKHRDKSY RYFNNINRLA KEYPLAHLAD PNTRVEVWCS NDYLNMGGHK  60
   61 KIREAMHQCI ETYGGGAGGT RNIAGHNQHA VRLEKSLADL HQKPAALVFG SCYVANDATL 120
  121 STLGRKLPNC IFLSDEMNHA SMINGIRNSR CEKIIFKHND LVDLEAKLAS LPLNRPKIIA 180
  181 FESVYSMSGN VAPISEICDL AKKYGAITFL DEVHAVGMYG PRGAGVAEET PGLLSRVDII 240
  241 TGTLAKSYGC VGGYIAASST LVDMIRSLAP GFIFTTSLPP HVMVGALTAV EHLKVSNVER 300
  301 EQQRSAVRRV KQSLSEIGIP VLSNDTHIVP AMVGDAHLAK LASDSLLHDH NIYVQSINFP 360
  361 TVSVGTERLR ITPTPAHNTE HYVQSLTNAM NDVWSKFNIN RIDGWEKRGI DVGRLCKFPV 420
  421 LPFTTTH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.0
Match: 2bwnA
Description: 5-Aminolevulinate Synthase from Rhodobacter capsulatus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
L-aspartate:2-oxoglutarate aminotransferase activity 3.359406422625 bayes_pls_golite062009
5-aminolevulinate synthase activity 3.15163480353521 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
N-succinyltransferase activity 1.81799375593294 bayes_pls_golite062009
threonine aldolase activity 1.80396420390785 bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity 1.74778109525713 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 1.63055151623667 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 1.63055151623667 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
transferase activity, transferring acyl groups 1.19150094103499 bayes_pls_golite062009
glycine C-acetyltransferase activity 0.935794708043259 bayes_pls_golite062009
transferase activity 0.737426388870721 bayes_pls_golite062009
carbon-sulfur lyase activity 0.698312655247044 bayes_pls_golite062009
vitamin binding 0.66463470119531 bayes_pls_golite062009
intramolecular transferase activity, transferring amino groups 0.659071155545801 bayes_pls_golite062009
binding 0.462716421837165 bayes_pls_golite062009
cystathionine beta-lyase activity 0.15938456446406 bayes_pls_golite062009
nucleic acid binding 0.0776397323445919 bayes_pls_golite062009
sulfurtransferase activity 0.0450490929307473 bayes_pls_golite062009
transcription regulator activity 0.0150950313851779 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle