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View Structure Prediction Details

Protein: pku80
Organism: Schizosaccharomyces pombe
Length: 695 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pku80.

Description E-value Query
Range
Subject
Range
gi|74005704 - gi|74005704|ref|XP_536061.2| PREDICTED: similar to ATP-dependent DNA helicase II [Canis familiaris]
582.0 [0..4] [689..103]
gi|74146893 - gi|74146893|dbj|BAE41402.1| unnamed protein product [Mus musculus]
581.0 [0..1] [689..1]
gi|1110531 - gi|1110531|gb|AAC52664.1| autoantigen Ku86
568.0 [0..2] [689..5]
gi|62896765 - gi|62896765|dbj|BAD96323.1| ATP-dependent DNA helicase II variant [Homo sapiens]
567.0 [0..3] [689..6]

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Predicted Domain #1
Region A:
Residues: [1-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDKECTVFV LDLGKDMGTC HHGRSHSDLE WTLSYFHDEL SHKFLANRKT DVVGIVGYKC  60
   61 DDTKNDLAEQ EAYWNISVLY PIQTALFSKL QSVSQTLKPS NTMQGDLISA IVVSFDLMAR 120
  121 HCKKNKWKKK MIVLTAARGI IDFSDYIGIA EQLLQHDVFL GVYGVDFDQE DINYSEPLKE 180
  181 SQKKENEVRI QEFVESCHGQ YCTFQQIYNN IGKPWVRKVR PVAIFRGTFS IGNRDSKDTS 240
  241 ISIQVERYPR TRLTKPPTSS AFYENDMSKN YECLNIENSN VENKSMESDA VSTVRSYMVR 300
  301 DPKTNDSFEV KREDLESGYS YGRTIVPISR SDEDVLALDT IPGYEILGFI PKSSLPIYYT 360
  361 ISDTNIIVPK DDFESKLNFS AFVQSLEREH RYALARFVSK DKGVPVLLVL MPYVEFKRHY 420
  421 LVDIQLPFAE DVRPYSFSEF EKLSNEEDMR QIDFAVSNYI DNMDLDSSDC GFNPPFEPEN 480
  481 TFSMIPHRLQ QAISYYANSP EGDLPQPNIY LTRYTNPPKS LLDNCILDLK LIKEKLTVNV 540
  541 PVKPKYSSQE TAFDTGAP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 119.0
Match: 1jeqB
Description: Ku80 subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
double-stranded telomeric DNA binding 8.64621483095491 bayes_pls_golite062009
telomeric DNA binding 5.16364366157397 bayes_pls_golite062009
binding 2.55976325410124 bayes_pls_golite062009
protein binding 1.4332924081006 bayes_pls_golite062009
transcription regulator activity 1.25153438703239 bayes_pls_golite062009
promoter binding 1.24066744801055 bayes_pls_golite062009
DNA-dependent ATPase activity 0.985753648509262 bayes_pls_golite062009
single-stranded DNA binding 0.814975395718076 bayes_pls_golite062009
DNA helicase activity 0.720743494912414 bayes_pls_golite062009
nucleic acid binding 0.655463239522058 bayes_pls_golite062009
transcription activator activity 0.53035927712834 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.506640285146188 bayes_pls_golite062009
DNA binding 0.496246846559375 bayes_pls_golite062009
structure-specific DNA binding 0.450760554291027 bayes_pls_golite062009
protein complex binding 0.31789779419928 bayes_pls_golite062009
protein C-terminus binding 0.15516806759612 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [559-695]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISEEQIEELL NSGLDEQEGE KLLVLHVSEK DPVGTFTEVL KNPFGLEDAL TEMEKVIKNL  60
   61 IDKSKYDLAL QSLQSLRLHS ILEDEVERFN EYLTRLKKDV MQNNKPKENE LINKIRSSGL 120
  121 DIILHDELTR HDNFNNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 1rw2A
Description: Three-dimensional structure of Ku80 CTD
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle