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View Structure Prediction Details

Protein: pst3
Organism: Schizosaccharomyces pombe
Length: 1154 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pst3.

Description E-value Query
Range
Subject
Range
gi|60359996 - gi|60359996|dbj|BAD90217.1| mKIAA4126 protein [Mus musculus]
1216.0 [0..1] [1132..13]
gi|34863481 - gi|34863481|ref|XP_343396.1| PREDICTED: similar to transcriptional regulator, SIN3A [Rattus norvegic...
1215.0 [0..1] [1132..5]
SIN3A - SIN3 homolog A, transcription regulator (yeast)
1214.0 [0..1] [1132..5]
gi|114658180, gi... - gi|114658188|ref|XP_001142956.1| PREDICTED: transcriptional co-repressor Sin3A isoform 11 [Pan trogl...
1214.0 [0..1] [1132..5]
gi|109081933 - gi|109081933|ref|XP_001103539.1| PREDICTED: similar to transcriptional co-repressor Sin3A isoform 5 ...
1214.0 [0..1] [1132..5]
gi|76662183, gi|... - gi|76662185|ref|XP_880544.1| PREDICTED: similar to transcriptional regulator, SIN3A isoform 6 [Bos t...
1205.0 [0..1] [1132..5]

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Predicted Domain #1
Region A:
Residues: [1-102]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVMNVPVDS ERDNPGDKVE TQSDKNHLPK ASPSQSQSPV NTSLHNGDGK DNGVATEPVE  60
   61 NKQILSERSV TRDDYEKGKT IVSSLALSSI SGKDGSISSQ NA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [103-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGLSSSSNRP LDVNDALSYL ELVKYYFSER REIYNRFLEI MRDFKSQALD TLGVINRVSE  60
   61 LFNGYPQLIE GFNTFLPSGY KIEVQLDSSN TSVVRVGTPM HPLPQQG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.0
Match: 2czyA
Description: Solution structure of the NRSF/REST-mSin3B PAH1 complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [210-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQSTLPVAPS NEDQRTMEST SPTDSQPQPS APNLVSSTEN EKPRVDFNYA IAYMNKVKAR  60
   61 YPPNSDTYME FLGVLRTYQK AQKSIFEVRA RVAEIFKDSP DLLEEFKLFL PDNVDSTEPS 120
  121 TPNVQKSPNR LPPVGNFSLP PSAPVREKRN RPAHSAQISR SISKTSRM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.221849
Match: 2f05A
Description: No description for 2f05A was found.

Predicted functions:

Term Confidence Notes
protein deacetylase activity 9.15317765173842 bayes_pls_golite062009
histone deacetylase activity 9.00540919224423 bayes_pls_golite062009
deacetylase activity 7.91874136549804 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6.08470985892139 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4.91057345050982 bayes_pls_golite062009
transcription repressor activity 4.58162229232685 bayes_pls_golite062009
transcription regulator activity 3.97924147512738 bayes_pls_golite062009
transcription corepressor activity 3.71696410617503 bayes_pls_golite062009
transcription factor binding 3.06004981994503 bayes_pls_golite062009
transcription cofactor activity 2.96293930027313 bayes_pls_golite062009
DNA binding 2.90699688513784 bayes_pls_golite062009
nucleic acid binding 2.89854237920034 bayes_pls_golite062009
binding 2.65480555250736 bayes_pls_golite062009
transcription factor activity 2.07660852403223 bayes_pls_golite062009
protein binding 1.46569798429756 bayes_pls_golite062009
transcription coactivator activity 1.06494495723884 bayes_pls_golite062009
transcription activator activity 0.63586266373929 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.599183685811182 bayes_pls_golite062009
catalytic activity 0.289349813503192 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [378-529]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRQTAEEPLN SYSLHVYPQK ITAPTSPYAA TQEELLAFTT IRQHLPDTLA FHKFLELLHL  60
   61 YREKLLDKTE LLNSFSKLVR NDNLTLWFSE FIRWSDNPIL VKNEPVDERV YLPETFECIS 120
  121 LTYRKLPDSW KQDKCSGRDD LDNSVLNDDY IS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.5
Match: 2f05A
Description: No description for 2f05A was found.

Predicted functions:

Term Confidence Notes
protein deacetylase activity 8.92489148049718 bayes_pls_golite062009
histone deacetylase activity 8.77562367748348 bayes_pls_golite062009
deacetylase activity 7.74805102638387 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5.99241841178307 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4.85992273034906 bayes_pls_golite062009
transcription repressor activity 4.25514230798992 bayes_pls_golite062009
transcription regulator activity 3.82193713323077 bayes_pls_golite062009
transcription corepressor activity 3.30769773581294 bayes_pls_golite062009
nucleic acid binding 2.83214064778422 bayes_pls_golite062009
DNA binding 2.82083682611814 bayes_pls_golite062009
transcription factor binding 2.73494763175272 bayes_pls_golite062009
transcription cofactor activity 2.59356984380124 bayes_pls_golite062009
binding 2.59005615358803 bayes_pls_golite062009
transcription factor activity 1.99794029160509 bayes_pls_golite062009
protein binding 1.36724461365736 bayes_pls_golite062009
transcription coactivator activity 0.918453145717461 bayes_pls_golite062009
transcription activator activity 0.570282420961288 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.512364998565023 bayes_pls_golite062009
catalytic activity 0.30211814650972 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [530-760]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAPKPSHVKN IMHHENQYLQ ALQLVEDERY DYDRVLNTTE SAIKILANFC EPTIHEHLET  60
   61 ALQELERSKR IIKNALIIVY GKEHANLALD TLFKKLPTAA PVLLKRIKTK DQEWRRSKRE 120
  121 WSKIWRQIEK KNAQAAFDDR YCRIEGRDRR GLSYSRILRD IDDIYQRQKH RIDGAKLGFQ 180
  181 FTQVLCDSLI FLNILRLSDA QLTNSSFYSY ADKGRISAVL KALLSQFFGI P

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [761-829]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPREALETNL ASENIESVKK HRDGLSKIFI RPESADNSNN TNVSFQTDET QTEDETMSDI  60
   61 HPDDVENHS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [830-1003]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSKFLGEESK NIIGYNFFGN ATMYVLFRLI CVCYSRLEHI KLFVESSTIY ASSTGGYENI  60
   61 LNICEKYLKG SCSRLEFRKY LQKFNNETCY MICSIERLLK VIFYRIHEIL LDPKLGQLLL 120
  121 LFESDGANSV TTPREQMVYR NHVESILAPE SKIFNMRWYP LEKRLCIQQL LPAD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1004-1154]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTMHDFENPA KAFMYYVDSY AISHITEGVD LMQVKMPFLR RSLQRISQQG YLAGRGSGRL  60
   61 HSLFNEHFCK SNLQLFFSTD TYVIFFEPNT ENVYINSYNL WVDQSSQSKK QNRTTNWRRW 120
  121 LESDEGWRKS KANTDIKFFS ETTLDQCIEA M

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle