YRC Public Data Repository - Protein Structure Prediction

Protein:	pst3
Organism:	Schizosaccharomyces pombe
Length:	1154 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pst3.

Description	E-value	Query Range	Subject Range
gi\|60359996 - gi\|60359996\|dbj\|BAD90217.1\| mKIAA4126 protein [Mus musculus]	1216.0	[0..1]	[1132..13]
gi\|34863481 - gi\|34863481\|ref\|XP_343396.1\| PREDICTED: similar to transcriptional regulator, SIN3A [Rattus norvegic...	1215.0	[0..1]	[1132..5]
SIN3A - SIN3 homolog A, transcription regulator (yeast)	1214.0	[0..1]	[1132..5]
gi\|114658180, gi... - gi\|114658188\|ref\|XP_001142956.1\| PREDICTED: transcriptional co-repressor Sin3A isoform 11 [Pan trogl...	1214.0	[0..1]	[1132..5]
gi\|109081933 - gi\|109081933\|ref\|XP_001103539.1\| PREDICTED: similar to transcriptional co-repressor Sin3A isoform 5 ...	1214.0	[0..1]	[1132..5]
gi\|76662183, gi\|... - gi\|76662185\|ref\|XP_880544.1\| PREDICTED: similar to transcriptional regulator, SIN3A isoform 6 [Bos t...	1205.0	[0..1]	[1132..5]

Back

Predicted Domain #1

Region A:
Residues: [1-102]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVMNVPVDS ERDNPGDKVE TQSDKNHLPK ASPSQSQSPV NTSLHNGDGK DNGVATEPVE  60
   61 NKQILSERSV TRDDYEKGKT IVSSLALSSI SGKDGSISSQ NA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [103-209]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGLSSSSNRP LDVNDALSYL ELVKYYFSER REIYNRFLEI MRDFKSQALD TLGVINRVSE  60
   61 LFNGYPQLIE GFNTFLPSGY KIEVQLDSSN TSVVRVGTPM HPLPQQG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.0
Match:	2czyA
Description:	Solution structure of the NRSF/REST-mSin3B PAH1 complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [210-377]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQSTLPVAPS NEDQRTMEST SPTDSQPQPS APNLVSSTEN EKPRVDFNYA IAYMNKVKAR  60
   61 YPPNSDTYME FLGVLRTYQK AQKSIFEVRA RVAEIFKDSP DLLEEFKLFL PDNVDSTEPS 120
  121 TPNVQKSPNR LPPVGNFSLP PSAPVREKRN RPAHSAQISR SISKTSRM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.221849
Match:	2f05A
Description:	No description for 2f05A was found.

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	9.15317765173842	bayes_pls_golite062009
histone deacetylase activity	9.00540919224423	bayes_pls_golite062009
deacetylase activity	7.91874136549804	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	6.08470985892139	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	4.91057345050982	bayes_pls_golite062009
transcription repressor activity	4.58162229232685	bayes_pls_golite062009
transcription regulator activity	3.97924147512738	bayes_pls_golite062009
transcription corepressor activity	3.71696410617503	bayes_pls_golite062009
transcription factor binding	3.06004981994503	bayes_pls_golite062009
transcription cofactor activity	2.96293930027313	bayes_pls_golite062009
DNA binding	2.90699688513784	bayes_pls_golite062009
nucleic acid binding	2.89854237920034	bayes_pls_golite062009
binding	2.65480555250736	bayes_pls_golite062009
transcription factor activity	2.07660852403223	bayes_pls_golite062009
protein binding	1.46569798429756	bayes_pls_golite062009
transcription coactivator activity	1.06494495723884	bayes_pls_golite062009
transcription activator activity	0.63586266373929	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.599183685811182	bayes_pls_golite062009
catalytic activity	0.289349813503192	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [378-529]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRQTAEEPLN SYSLHVYPQK ITAPTSPYAA TQEELLAFTT IRQHLPDTLA FHKFLELLHL  60
   61 YREKLLDKTE LLNSFSKLVR NDNLTLWFSE FIRWSDNPIL VKNEPVDERV YLPETFECIS 120
  121 LTYRKLPDSW KQDKCSGRDD LDNSVLNDDY IS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.5
Match:	2f05A
Description:	No description for 2f05A was found.

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	8.92489148049718	bayes_pls_golite062009
histone deacetylase activity	8.77562367748348	bayes_pls_golite062009
deacetylase activity	7.74805102638387	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	5.99241841178307	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	4.85992273034906	bayes_pls_golite062009
transcription repressor activity	4.25514230798992	bayes_pls_golite062009
transcription regulator activity	3.82193713323077	bayes_pls_golite062009
transcription corepressor activity	3.30769773581294	bayes_pls_golite062009
nucleic acid binding	2.83214064778422	bayes_pls_golite062009
DNA binding	2.82083682611814	bayes_pls_golite062009
transcription factor binding	2.73494763175272	bayes_pls_golite062009
transcription cofactor activity	2.59356984380124	bayes_pls_golite062009
binding	2.59005615358803	bayes_pls_golite062009
transcription factor activity	1.99794029160509	bayes_pls_golite062009
protein binding	1.36724461365736	bayes_pls_golite062009
transcription coactivator activity	0.918453145717461	bayes_pls_golite062009
transcription activator activity	0.570282420961288	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.512364998565023	bayes_pls_golite062009
catalytic activity	0.30211814650972	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [530-760]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAPKPSHVKN IMHHENQYLQ ALQLVEDERY DYDRVLNTTE SAIKILANFC EPTIHEHLET  60
   61 ALQELERSKR IIKNALIIVY GKEHANLALD TLFKKLPTAA PVLLKRIKTK DQEWRRSKRE 120
  121 WSKIWRQIEK KNAQAAFDDR YCRIEGRDRR GLSYSRILRD IDDIYQRQKH RIDGAKLGFQ 180
  181 FTQVLCDSLI FLNILRLSDA QLTNSSFYSY ADKGRISAVL KALLSQFFGI P

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [761-829]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPREALETNL ASENIESVKK HRDGLSKIFI RPESADNSNN TNVSFQTDET QTEDETMSDI  60
   61 HPDDVENHS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [830-1003]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSKFLGEESK NIIGYNFFGN ATMYVLFRLI CVCYSRLEHI KLFVESSTIY ASSTGGYENI  60
   61 LNICEKYLKG SCSRLEFRKY LQKFNNETCY MICSIERLLK VIFYRIHEIL LDPKLGQLLL 120
  121 LFESDGANSV TTPREQMVYR NHVESILAPE SKIFNMRWYP LEKRLCIQQL LPAD

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8

Region A:
Residues: [1004-1154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTMHDFENPA KAFMYYVDSY AISHITEGVD LMQVKMPFLR RSLQRISQQG YLAGRGSGRL  60
   61 HSLFNEHFCK SNLQLFFSTD TYVIFFEPNT ENVYINSYNL WVDQSSQSKK QNRTTNWRRW 120
  121 LESDEGWRKS KANTDIKFFS ETTLDQCIEA M

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.330	0.116	histone deacetylation	d.129.1	TATA-box binding protein-like
View	Download	0.259	0.065	histone deacetylation	d.110.4	SNARE-like
View	Download	0.257	0.039	histone deacetylation	d.39.1	Dynein light chain 8 (DLC8)
View	Download	0.289	N/A	N/A	d.129.1	TATA-box binding protein-like
View	Download	0.226	N/A	N/A	d.110.4	SNARE-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: