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View Structure Prediction Details

Protein: ppk3
Organism: Schizosaccharomyces pombe
Length: 637 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ppk3.

Description E-value Query
Range
Subject
Range
gi|115430243, gi... - gi|14041817|dbj|BAB55459.1| kinase-like protein splice variant 1 [Homo sapiens], gi|119594802|gb|EAW...
317.0 [0..10] [634..4]
gi|73983692 - gi|73983692|ref|XP_540858.2| PREDICTED: similar to SCY1-like 1 [Canis familiaris]
313.0 [0..34] [634..29]
gi|76658144, gi|... - gi|76658144|ref|XP_874349.1| PREDICTED: similar to SCY1-like 1 isoform 2 [Bos taurus], gi|119919261|...
306.0 [0..34] [634..29]
gi|21961588 - gi|21961588|gb|AAH34519.1| SCY1-like 1 (S. cerevisiae) [Mus musculus]
303.0 [0..34] [634..29]

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Predicted Domain #1
Region A:
Residues: [1-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFIKSAASF IAKAGSQFPY DLNEKIPLSS NSVWTLQTGS IRESAQPCSV FSISLSTHPE  60
   61 WAELADRACE TMKTLRHPCI IKYLSTYKSS THLYIATETV RPVTTELNEL SAEIKTYGLW 120
  121 RVSAALSFLN DKNIVHGNLQ MSSVYLNSAD EWIIGDFFLA GDSPQFIKDN HDKILNWSRL 180
  181 VPFEIQSSTL NSASFIYLDS YELGKFISHL YNGTPGDLSQ RGNIPANIFV SAKKLLNVEG 240
  241 KQKLLASEFL KLGERPGGFF RTHLITLYEL LSEVRINEEE DRVKLKQLLS SKLEVIPKNY 300
  301 IQKVVLNILF LLLSIDTHSD VVELLFKCAQ IVKGRPDIEK DFGVPLLSLL KQQSVPIRGL 360
  361 LLSGIINNPD VLPKNIYEDT SFSVFANLVR SNSPTLKEHA IVVFSIIAPK LSKKTLNNEL 420
  421 LRSLAVVQND QH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.09691
Match: 1omwA
Description: G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.52009208560575 bayes_pls_golite062009
binding 2.26863398810301 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.07522371528074 bayes_pls_golite062009
protein kinase activity 1.05576788307899 bayes_pls_golite062009
kinase activity 1.02766245357265 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.864377119360303 bayes_pls_golite062009
Ran GTPase binding 0.69155782303647 bayes_pls_golite062009
protein serine/threonine kinase activity 0.611829373978789 bayes_pls_golite062009
enzyme binding 0.42115599703234 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
transferase activity 0.351512711954014 bayes_pls_golite062009
receptor signaling protein activity 0.173125467317897 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.0884767565575595 bayes_pls_golite062009
transporter activity 0.0356867444078989 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [433-557]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTLRTNSTIC LGKIAEYLDA SVRKPVLAAA LSRSLKDPFV PAREAALKVL LSVQNYFDTK  60
   61 DVAIKLFPSV VPLLIDENEG IRRTAEDVTD QFLSRIKNFN LGEKENVSAP AKFNGSFWSK 120
  121 FIHSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.522879
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [558-637]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASPSPSIDM KKESLELKND TTEIKEKKNS KSRVVGNTEN SKDEFNNPLF ETEEQIDESW  60
   61 MENWNDEEET ENNVEESWGL 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle