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View Structure Prediction Details

Protein: set3
Organism: Schizosaccharomyces pombe
Length: 859 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for set3.

Description E-value Query
Range
Subject
Range
gi|10438794 - gi|10438794|dbj|BAB15346.1| unnamed protein product [Homo sapiens]
439.0 [0..8] [859..83]
gi|109079962 - gi|109079962|ref|XP_001094467.1| PREDICTED: similar to nuclear receptor binding SET domain protein 1...
416.0 [0..8] [859..1354]
gi|114603599, gi... - gi|114603601|ref|XP_001139522.1| PREDICTED: nuclear receptor binding SET domain protein 1 isoform 6 ...
413.0 [0..8] [859..1442]
gi|109504622, gi... - gi|109505410|ref|XP_001066409.1| PREDICTED: similar to nuclear receptor binding SET domain protein 1...
411.0 [0..8] [859..1708]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWKIRCVCPF EDDDGFTIQC ESCEVWQHAV CVNIDANNVP EKYFCEQCQP RPIDADKAHK  60
   61 IQLARLQREE EQSRILS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.522879
Match: 1wemA
Description: Solution structure of PHD domain in death inducer-obliterator 1(DIO-1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 4.57883938223258 bayes_pls_golite062009
histone deacetylase activity 4.49333137949283 bayes_pls_golite062009
methylated histone residue binding 4.19057851212315 bayes_pls_golite062009
deacetylase activity 3.63389424240028 bayes_pls_golite062009
histone acetyltransferase activity 3.20023500652896 bayes_pls_golite062009
lysine N-acetyltransferase activity 3.20023500652896 bayes_pls_golite062009
histone binding 3.01402804224903 bayes_pls_golite062009
binding 2.78627791259335 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.32449645578286 bayes_pls_golite062009
histone methyltransferase activity 2.02130427551376 bayes_pls_golite062009
nucleosome binding 1.69494047037058 bayes_pls_golite062009
protein binding 1.6308789519356 bayes_pls_golite062009
protein methyltransferase activity 1.49667541832007 bayes_pls_golite062009
1.38236406424542 bayes_pls_golite062009
lysine N-methyltransferase activity 1.3339105639569 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.3339105639569 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.3339105639569 bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific) 1.2339461840955 bayes_pls_golite062009
N-acetyltransferase activity 1.19037129579681 bayes_pls_golite062009
chromatin binding 1.0360039180364 bayes_pls_golite062009
nucleic acid binding 1.01735624308761 bayes_pls_golite062009
DNA binding 0.896491359501813 bayes_pls_golite062009
N-acyltransferase activity 0.873079221910902 bayes_pls_golite062009
transcription regulator activity 0.723245820583374 bayes_pls_golite062009
protein kinase activity 0.405766438875014 bayes_pls_golite062009
acetyltransferase activity 0.39905022319963 bayes_pls_golite062009
cytoskeletal protein binding 0.327424740985033 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.14235705491362 bayes_pls_golite062009
N-methyltransferase activity 0.137650352572163 bayes_pls_golite062009
0.0927457062201698 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0901653273812402 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0710710324092494 bayes_pls_golite062009
histone acetyl-lysine binding 0.0410393640547611 bayes_pls_golite062009
kinase activity 0.00387875923819597 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [78-356]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSRSSNNKRR TSFGKNGASP THSASPRQGN NTGANGALFS QSTNSSNSGS YRNSVTGATL  60
   61 PNAHAPHSQN RRRRSNHLNN PPEAPITEAS NEYVYSFHLE YVPLESNTFS ASALEYSKNL 120
  121 DLKNLDESEV LMDGCQVVPI SSSKFCCSRF GLVSTCEIPP NTPIMEVKGR VCTQNEYKSD 180
  181 PKNQYNILGA PKPHVFFDSN SQLVVDSRVA GSKARFARKG CQSNSVVSSV YMNGSNSVPR 240
  241 FILYSTTHIA PETEIIGDWT LDISHPFRQF APGMSRPSF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.045757
Match: 2igqA
Description: No description for 2igqA was found.

Predicted Domain #3
Region A:
Residues: [357-531]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NMEELELLSE VLSTFLSFNE CASQDKKNCV FSRVTKYIKA ARRASTANRV SVAKDRLSLT  60
   61 PSSTPSTPSP AESLPQPSNP TSVYAKSLKE FWLDKYRLSI LQKWPAVKSL PTESVGIDVV 120
  121 MEPKLQPSVK EKKPTKDLQS PLPSVEEDSS NRDKKTDIAD LHTDSKVGIA DVLSP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [532-717]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISPDAALQSD GPLKKAKEPE ESSITPTTPP SFNVGESLSR RSASPLQHPR TSPDMLDKTS  60
   61 PCKRGLGTIT TVHKKHGSVD HLPSVKRRRS IANDFHGKPD YNKRSLSIER KPEAFKTKGD 120
  121 RPHKVHPSFH RNSDSKLKLE PSSKEKSGSM FFNTLRTVKD KSHVHDTQRS SDVNFSRQNG 180
  181 TRSHSP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [718-859]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVSPVGFSFD KSPVTTPPLP TAPAPVITSR HALVNNQFPT NNPNILDHKA NNGDDISNAL  60
   61 NTSRSENKPN SNLVQGSVVK PSNTSASALP TSAPKKLSLS EYRQRRQQNI LHQQSKDNQA 120
  121 HGDTARPHTV PAATVSNPSF TR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle