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View Structure Prediction Details

Protein: cip2
Organism: Schizosaccharomyces pombe
Length: 576 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cip2.

Description E-value Query
Range
Subject
Range
gi|76689263 - gi|76689263|ref|XP_880772.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 1 ...
293.0 [0..59] [541..1]
gi|73976803 - gi|73976803|ref|XP_857821.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
292.0 [0..59] [576..1]
gi|55959640, gi|... - gi|55962218|emb|CAI12299.1| poly(A) binding protein, cytoplasmic 4 (inducible form) [Homo sapiens], ...
291.0 [0..59] [576..1]

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Predicted Domain #1
Region A:
Residues: [1-126]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEGTSQRPL TPLSQAFLST NTLSPASSPL TFHSEAASLR RKRSNFFPKL DELNGAQDEE  60
   61 MRGLNIPGGS GYLENRYGRD KFTFSDAAVN SAGMGGSGIF SHNNADDGLG DGSSTVLPSS 120
  121 LKQMLD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [127-221]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEISTANNPS AKPRRTRLQT AWKEATNSAG LSLRSASALD VLKNSGPATT SLLSSTTYPF  60
   61 DSLNAFNEPS HSHVPNSASS TALSRGMSNS VTLTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.39794
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.63987691433124 bayes_pls_golite062009
nucleic acid binding 4.05055109233024 bayes_pls_golite062009
mRNA binding 3.54495985180603 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
1.35163561991147 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 0.884269546056316 bayes_pls_golite062009
DNA binding 0.841333741555926 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
poly-pyrimidine tract binding 0.544292786424842 bayes_pls_golite062009
transcription factor activity 0.182209144070426 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [222-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPEPDEETIP TAIVIKNIPF SLKKEVLFKV FTALDIPRPY AFNYHFDNGV FRGLAFANFH  60
   61 SPEEAKTVVQ VLNGYEITGR RLRVEWKRQL PPAERERVER GKQEKRAVEE RKNQLKSPFS 120
  121 VANIGAGIDF DLNDPAILNV YSHILLFYYR SDNTNDLVFD SSTTQEERRV AALLASRLNL 180
  181 NHSVTGDGEA KQVVITMPST HFTPANNSSA NH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.522879
Match: 1l3kA
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.63987691433124 bayes_pls_golite062009
nucleic acid binding 4.05055109233024 bayes_pls_golite062009
mRNA binding 3.54495985180603 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
1.35163561991147 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 0.884269546056316 bayes_pls_golite062009
DNA binding 0.841333741555926 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
poly-pyrimidine tract binding 0.544292786424842 bayes_pls_golite062009
transcription factor activity 0.182209144070426 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [434-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLMAPNAST LNPSSLGASN LSQPSLANHL SSSGLFDNGL FSSGGLSSNF SSLRRPAPSM  60
   61 HLADSIRSLR GLNDSKAFSD IRSMPATPLE LATPFANLNV SSPLDRNATN SSNTLNGSAM 120
  121 NDYFASLTPS NTGAIGSRTF TKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle