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View Structure Prediction Details

Protein: cip2
Organism: Schizosaccharomyces pombe
Length: 576 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cip2.

Description E-value Query
Range
Subject
Range
gi|76689263 - gi|76689263|ref|XP_880772.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 1 ...
293.0 [0..59] [541..1]
gi|73976803 - gi|73976803|ref|XP_857821.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
292.0 [0..59] [576..1]
gi|55959640, gi|... - gi|55962218|emb|CAI12299.1| poly(A) binding protein, cytoplasmic 4 (inducible form) [Homo sapiens], ...
291.0 [0..59] [576..1]

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Predicted Domain #1
Region A:
Residues: [1-126]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEGTSQRPL TPLSQAFLST NTLSPASSPL TFHSEAASLR RKRSNFFPKL DELNGAQDEE  60
   61 MRGLNIPGGS GYLENRYGRD KFTFSDAAVN SAGMGGSGIF SHNNADDGLG DGSSTVLPSS 120
  121 LKQMLD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.292 0.056 response to oxidative stress a.22.1 Histone-fold
View Download 0.222 0.024 response to oxidative stress a.74.1 Cyclin-like
View Download 0.275 0.009 response to oxidative stress a.60.9 lambda integrase-like, N-terminal domain
View Download 0.214 N/A N/A a.22.1 Histone-fold

Predicted Domain #2
Region A:
Residues: [127-221]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEISTANNPS AKPRRTRLQT AWKEATNSAG LSLRSASALD VLKNSGPATT SLLSSTTYPF  60
   61 DSLNAFNEPS HSHVPNSASS TALSRGMSNS VTLTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.39794
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.63987691433124 bayes_pls_golite062009
nucleic acid binding 4.05055109233024 bayes_pls_golite062009
mRNA binding 3.54495985180603 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
1.35163561991147 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 0.884269546056316 bayes_pls_golite062009
DNA binding 0.841333741555926 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
poly-pyrimidine tract binding 0.544292786424842 bayes_pls_golite062009
transcription factor activity 0.182209144070426 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [222-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPEPDEETIP TAIVIKNIPF SLKKEVLFKV FTALDIPRPY AFNYHFDNGV FRGLAFANFH  60
   61 SPEEAKTVVQ VLNGYEITGR RLRVEWKRQL PPAERERVER GKQEKRAVEE RKNQLKSPFS 120
  121 VANIGAGIDF DLNDPAILNV YSHILLFYYR SDNTNDLVFD SSTTQEERRV AALLASRLNL 180
  181 NHSVTGDGEA KQVVITMPST HFTPANNSSA NH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.522879
Match: 1l3kA
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.63987691433124 bayes_pls_golite062009
nucleic acid binding 4.05055109233024 bayes_pls_golite062009
mRNA binding 3.54495985180603 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
1.35163561991147 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 0.884269546056316 bayes_pls_golite062009
DNA binding 0.841333741555926 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
poly-pyrimidine tract binding 0.544292786424842 bayes_pls_golite062009
transcription factor activity 0.182209144070426 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [434-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLMAPNAST LNPSSLGASN LSQPSLANHL SSSGLFDNGL FSSGGLSSNF SSLRRPAPSM  60
   61 HLADSIRSLR GLNDSKAFSD IRSMPATPLE LATPFANLNV SSPLDRNATN SSNTLNGSAM 120
  121 NDYFASLTPS NTGAIGSRTF TKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle