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View Structure Prediction Details

Protein: swi6
Organism: Schizosaccharomyces pombe
Length: 328 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for swi6.

Description E-value Query
Range		 Subject
Range
gi|109129375 - gi|109129375|ref|XP_001108466.1| PREDICTED: similar to chromodomain protein, Y-like 2 [Macaca mulatt...
 169.0 [0..74] [313..97]
gi|32479352 - gi|32479352|gb|AAP83841.1| chromodomain Y-like protein 2 [Macaca fascicularis]
 167.0 [0..79] [313..5]
CDYL2 - chromodomain protein, Y-like 2
 164.0 [0..79] [313..5]
gi|114663884 - gi|114663884|ref|XP_523432.2| PREDICTED: chromodomain protein, Y-like 2 [Pan troglodytes]
 164.0 [0..83] [313..49]
gi|74206467 - gi|74206467|dbj|BAE24934.1| unnamed protein product [Mus musculus]
 158.0 [0..79] [313..5]
CHP2_SCHPO - Chromo domain-containing protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=chp2 PE...
chp2 - chromodomain protein 2
 157.0 [0..4] [324..94]
gi|109508956 - gi|109508956|ref|XP_001078221.1| PREDICTED: similar to chromodomain Y-like protein 2 [Rattus norvegi...
 153.0 [0..83] [313..7]

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Predicted Domain #1
Region A:
Residues: [1-76] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKGGVRSYR RSSTSKRSVI DDDSEPELPS MTKEAIASHK ADSGSSDNEV ESDHESKSSS  60
   61 KKLKENAKEE EGGEEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [77-172] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEDEYVVEKV LKHRMARKGG GYEYLLKWEG YDDPSDNTWS SEADCSGCKQ LIEAYWNEHG  60
   61 GRPEPSKRKR TARPKKPEAK EPSPKSRKTD EDKHDK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.30103
Match: 2b2uA
Description: Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
chromatin binding 3.1924157640698 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
methylated histone residue binding 2.71235155233989 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
histone binding 1.48525673080866 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [173-255] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSNEKIEDVN EKTIKFADKS QEEFNENGPP SGQPNGHIES DNESKSPSQK ESNESEDIQI  60
   61 AETPSNVTPK KKPSPEVPKL PDN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [256-328] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RELTVKQVEN YDSWEDLVSS IDTIERKDDG TLEIYLTWKN GAISHHPSTI TNKKCPQKML  60
   61 QFYESHLTFR ENE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.154902
Match: 1e0bA
Description: Heterochromatin protein 1, HP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
chromatin binding 3.1924157640698 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
methylated histone residue binding 2.71235155233989 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
histone binding 1.48525673080866 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle