YRC Public Data Repository - Protein Structure Prediction

Protein:	ura5
Organism:	Schizosaccharomyces pombe
Length:	215 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ura5.

Description	E-value	Query Range	Subject Range
gi\|89093848, gi\|... - gi\|89093848\|ref\|ZP_01166794.1\| orotate phosphoribosyltransferase [Oceanospirillum sp. MED92], gi\|890...	183.0	[0..2]	[215..3]
PYRE_VIBCH - Orotate phosphoribosyltransferase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N... gi\|254847045, gi... - gi\|254851340\|ref\|ZP_05240690.1\| orotate phosphoribosyltransferase [Vibrio cholerae MO10], gi\|2548470... PYRE_VIBCH - Orotate phosphoribosyltransferase OS=Vibrio cholerae GN=pyrE PE=1 SV=2	180.0	[0..2]	[214..3]
gi\|229356093, gi... - gi\|229506988\|ref\|ZP_04396496.1\| orotate phosphoribosyltransferase [Vibrio cholerae BX 330286], gi\|22... gi\|229512475, gi... - gi\|229512475\|ref\|ZP_04401947.1\| orotate phosphoribosyltransferase [Vibrio cholerae TMA 21], gi\|22935... gi\|229516305, gi... - gi\|229516305\|ref\|ZP_04405753.1\| orotate phosphoribosyltransferase [Vibrio cholerae RC9], gi\|22934673... gi\|229369151, gi... - gi\|229606496\|ref\|YP_002877144.1\| orotate phosphoribosyltransferase [Vibrio cholerae MJ-1236], gi\|229... gi\|124118745, gi... - gi\|153222605\|ref\|ZP_01953309.1\| orotate phosphoribosyltransferase [Vibrio cholerae MAK 757], gi\|1241... gi\|75830214, gi\|... - gi\|75830214\|ref\|ZP_00759496.1\| COG0461: Orotate phosphoribosyltransferase [Vibrio cholerae MO10], gi... gi\|126509508, gi... - gi\|153819944\|ref\|ZP_01972611.1\| orotate phosphoribosyltransferase [Vibrio cholerae NCTC 8457], gi\|12... gi\|229509358, gi... - gi\|229509358\|ref\|ZP_04398841.1\| orotate phosphoribosyltransferase [Vibrio cholerae B33], gi\|22935367... PYRE_VIBCH - (Q9KVD5) Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRT) (OPRTase) gi\|9654618, gi\|1... - gi\|9654618\|gb\|AAF93387.1\| orotate phosphoribosyltransferase [Vibrio cholerae O1 biovar El Tor str. N... gi\|150422455, gi... - gi\|254291598\|ref\|ZP_04962387.1\| orotate phosphoribosyltransferase [Vibrio cholerae AM-19226], gi\|197... gi\|227080432, gi... - gi\|227080432\|ref\|YP_002808983.1\| orotate phosphoribosyltransferase [Vibrio cholerae M66-2], gi\|22700...	180.0	[0..2]	[214..4]
gi\|75816555 - gi\|75816555\|ref\|ZP_00747022.1\| COG0461: Orotate phosphoribosyltransferase [Vibrio cholerae V52] gi\|75828202 - gi\|75828202\|ref\|ZP_00757637.1\| COG0461: Orotate phosphoribosyltransferase [Vibrio cholerae O395]	179.0	[0..2]	[214..3]
gi\|85711492, gi\|... - gi\|85711492\|ref\|ZP_01042550.1\| orotate phosphoribosyltransferase [Idiomarina baltica OS145], gi\|8569...	178.0	[0..3]	[214..4]
gi\|56461526, gi\|... - gi\|56461526\|ref\|YP_156807.1\| orotate phosphoribosyltransferase [Idiomarina loihiensis L2TR], gi\|5618...	177.0	[0..2]	[214..3]
PYRE_VIBPA - Orotate phosphoribosyltransferase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN... gi\|149748730, gi... - gi\|153837867\|ref\|ZP_01990534.1\| orotate phosphoribosyltransferase [Vibrio parahaemolyticus AQ3810], ... PYRE_VIBPA - Orotate phosphoribosyltransferase OS=Vibrio parahaemolyticus GN=pyrE PE=3 SV=1	177.0	[0..2]	[214..3]
gi\|116220658, gi... - gi\|75819962\|ref\|ZP_00750022.1\| COG0461: Orotate phosphoribosyltransferase [Vibrio cholerae V51], gi\|...	177.0	[0..2]	[214..3]
PYRE_PHOLL - Orotate phosphoribosyltransferase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / C... PYRE_PHOLL - Orotate phosphoribosyltransferase OS=Photorhabdus luminescens subsp. laumondii GN=pyrE PE=3 SV=1	176.0	[0..2]	[214..3]
gi\|207088350 - gi\|207088350\|gb\|EDZ65622.1\| orotate phosphoribosyltransferase [Nitrosococcus oceani AFC27] PYRE_NITOC - Orotate phosphoribosyltransferase OS=Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848) GN=pyrE ... gi\|224408696, gi... - gi\|254435239\|ref\|ZP_05048746.1\| orotate phosphoribosyltransferase [Nitrosococcus oceani AFC27], gi\|2...	176.0	[0..2]	[215..3]

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Predicted Domain #1

Region A:
Residues: [1-215]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKLELLRR ALEHNVLKFG TFTLKSGRKS PYFFNSGNFT HGADLCALAE AYAETIIAMN  60
   61 VDFDVIFGPA YKGISLAAIT AVKLYEKTGK SYGFAYNRKE AKSHGEGGNL VGAEMEGKKV 120
  121 LLLDDVITAG TAIREAISFL EPKHVKLAGI VLLLDRQERL DPEVNESTIG RLKKELNLPV 180
  181 SSILTLDDIV DFTKSDLTAA ESKAMDAYRQ QYQAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.69897
Match:	1lh0A
Description:	Orotate PRTase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
adenine phosphoribosyltransferase activity	3.1748712918814	bayes_pls_golite062009
uracil phosphoribosyltransferase activity	3.0470646511978	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	2.97347277288245	bayes_pls_golite062009
transferase activity	2.73727660668741	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.21367942706564	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	2.02298774328915	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	1.51875493459374	bayes_pls_golite062009
nucleobase binding	1.28671115202467	bayes_pls_golite062009
purine binding	1.24786927434743	bayes_pls_golite062009
amidophosphoribosyltransferase activity	0.932396739123353	bayes_pls_golite062009
binding	0.847513071499147	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
nucleic acid binding	0.552133387792911	bayes_pls_golite062009
DNA binding	0.439741935655503	bayes_pls_golite062009
transcription regulator activity	0.396538943915776	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: