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View Structure Prediction Details

Protein: mei4
Organism: Schizosaccharomyces pombe
Length: 517 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mei4.

Description E-value Query
Range
Subject
Range
gi|54657094 - gi|54657094|gb|EAL35927.1| DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain [Cryptosporidiu...
gi|67597591 - gi|67597591|ref|XP_666157.1| DNA-directed RNA polymerase II largest chain [Cryptosporidium hominis T...
166.0 [0..207] [508..1539]
gi|3511287, gi|7... - pir||T31670 DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain - Mastigamoeba invertens (frag...
153.0 [0..148] [505..1334]
TCNA_TRYCR - Sialidase OS=Trypanosoma cruzi GN=TCNA PE=2 SV=1
148.0 [0..13] [515..599]
gi|4808166 - gi|4808166|emb|CAB42797.1| largest subunit of the RNA polymerase II complex [Drosophila pseudoobscur...
144.0 [0..131] [511..1407]
gi|12642614 - gi|12642614|gb|AAK00311.1|AF315821_1 DNA-dependent RNA polymerase II largest subunit RPB1 [Monosiga ...
142.0 [0..156] [495..1385]
gi|158332, gi|279533 - pir||RNFF2L DNA-directed RNA polymerase (EC 2.7.7.6) II 215K chain [validated] - fruit fly (Drosophi...
139.0 [0..146] [511..1496]
gi|7494579 - gi|7494579|pir||T29959 DNA-directed RNA polymerase II large subunit ama-1 - Caenorhabditis elegans
138.0 [0..180] [505..1501]
gi|9587193, gi|9... - gi|9587199|gb|AAF89203.1|AF272653_1 RNA polymerase II largest subunit [Drosophila subobscura], gi|95...
130.0 [0..140] [511..1476]
RPB1_CAEBR - DNA-directed RNA polymerase II subunit RPB1 OS=Caenorhabditis briggsae GN=rpb-1 PE=3 SV=2
gi|157759005 - gi|157759005|ref|XP_001671846.1| Hypothetical protein CBG05355 [Caenorhabditis briggsae AF16]
128.0 [0..182] [514..1497]

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Predicted Domain #1
Region A:
Residues: [1-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVENQGNVEA HGKPKKVILS LSLKESSKIN DSQNVSNVSS KEKCETEALL REENKENLSS  60
   61 DSIRQMIFGD EMAGFVDTGE KPPCSYATLI GLAILQSHNK QLTLSGIYTW IRNTFRYYLN 120
  121 HDGGWQNSIR HNLSLNKAFI KVEKPKGKTL KGHYWTIDPD HMQNFVSVRL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.0
Match: 1d5vA
Description: Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [171-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRSHSTDSNS KKRPSSKCHE IKPLTTREIP LARKRSRLNS FNSSTSTSGS SSNVAAEVSN  60
   61 DASQPSNQDS SLNSNIVKPP LPPSNVQSNS SSSENVPKPN AETQEDLPTI DAHE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [285-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLYENVNDS RLYEVPACRN MALNTGYSDA DPGYLRTSFR SNSHNSLPYS ANEEEDVLQA  60
   61 DFLVSQQSSM VSSYVSSRDP HSMPYYRREP IPLRPSSRFY EYTRPTYGRT DTSCSAPGAF 120
  121 CSTQINSPSS YINYSKCAPS SPTLSLQKHR EHVKSLLYVP DLTPSFDGSD PWNPSSQLLS 180
  181 EPLFDQHSFQ SSLDDLMSVT CFRDSPELNH ESSGYSSAPL MPSNRAFIND FSL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle