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View Structure Prediction Details

Protein: mei4
Organism: Schizosaccharomyces pombe
Length: 517 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mei4.

Description E-value Query
Range
Subject
Range
gi|54657094 - gi|54657094|gb|EAL35927.1| DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain [Cryptosporidiu...
gi|67597591 - gi|67597591|ref|XP_666157.1| DNA-directed RNA polymerase II largest chain [Cryptosporidium hominis T...
166.0 [0..207] [508..1539]
gi|3511287, gi|7... - pir||T31670 DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain - Mastigamoeba invertens (frag...
153.0 [0..148] [505..1334]
TCNA_TRYCR - Sialidase OS=Trypanosoma cruzi GN=TCNA PE=2 SV=1
148.0 [0..13] [515..599]
gi|4808166 - gi|4808166|emb|CAB42797.1| largest subunit of the RNA polymerase II complex [Drosophila pseudoobscur...
144.0 [0..131] [511..1407]
gi|12642614 - gi|12642614|gb|AAK00311.1|AF315821_1 DNA-dependent RNA polymerase II largest subunit RPB1 [Monosiga ...
142.0 [0..156] [495..1385]
gi|158332, gi|279533 - pir||RNFF2L DNA-directed RNA polymerase (EC 2.7.7.6) II 215K chain [validated] - fruit fly (Drosophi...
139.0 [0..146] [511..1496]
gi|7494579 - gi|7494579|pir||T29959 DNA-directed RNA polymerase II large subunit ama-1 - Caenorhabditis elegans
138.0 [0..180] [505..1501]
gi|9587193, gi|9... - gi|9587199|gb|AAF89203.1|AF272653_1 RNA polymerase II largest subunit [Drosophila subobscura], gi|95...
130.0 [0..140] [511..1476]
RPB1_CAEBR - DNA-directed RNA polymerase II subunit RPB1 OS=Caenorhabditis briggsae GN=rpb-1 PE=3 SV=2
gi|157759005 - gi|157759005|ref|XP_001671846.1| Hypothetical protein CBG05355 [Caenorhabditis briggsae AF16]
128.0 [0..182] [514..1497]

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Predicted Domain #1
Region A:
Residues: [1-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVENQGNVEA HGKPKKVILS LSLKESSKIN DSQNVSNVSS KEKCETEALL REENKENLSS  60
   61 DSIRQMIFGD EMAGFVDTGE KPPCSYATLI GLAILQSHNK QLTLSGIYTW IRNTFRYYLN 120
  121 HDGGWQNSIR HNLSLNKAFI KVEKPKGKTL KGHYWTIDPD HMQNFVSVRL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.0
Match: 1d5vA
Description: Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [171-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRSHSTDSNS KKRPSSKCHE IKPLTTREIP LARKRSRLNS FNSSTSTSGS SSNVAAEVSN  60
   61 DASQPSNQDS SLNSNIVKPP LPPSNVQSNS SSSENVPKPN AETQEDLPTI DAHE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [285-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLYENVNDS RLYEVPACRN MALNTGYSDA DPGYLRTSFR SNSHNSLPYS ANEEEDVLQA  60
   61 DFLVSQQSSM VSSYVSSRDP HSMPYYRREP IPLRPSSRFY EYTRPTYGRT DTSCSAPGAF 120
  121 CSTQINSPSS YINYSKCAPS SPTLSLQKHR EHVKSLLYVP DLTPSFDGSD PWNPSSQLLS 180
  181 EPLFDQHSFQ SSLDDLMSVT CFRDSPELNH ESSGYSSAPL MPSNRAFIND FSL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle