YRC Public Data Repository - Protein Structure Prediction

Protein:	hem2
Organism:	Schizosaccharomyces pombe
Length:	329 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hem2.

Description	E-value	Query Range	Subject Range
gi\|86607365, gi\|... - gi\|86607365\|ref\|YP_476128.1\| delta-aminolevulinic acid dehydratase [Synechococcus sp. JA-3-3Ab], gi\|... gi\|86607365 - gi\|86607365\|ref\|YP_476128.1\| delta-aminolevulinic acid dehydratase [Cyanobacteria bacterium Yellowst...	553.0	[0..1]	[328..1]
gi\|86609891 - gi\|86609891\|ref\|YP_478653.1\| delta-aminolevulinic acid dehydratase [Cyanobacteria bacterium Yellowst... gi\|86558433, gi\|... - gi\|86609891\|ref\|YP_478653.1\| delta-aminolevulinic acid dehydratase [Synechococcus sp. JA-2-3B'a(2-13...	549.0	[0..1]	[328..1]
gi\|83573008, gi\|... - gi\|83590094\|ref\|YP_430103.1\| delta-aminolevulinic acid dehydratase [Moorella thermoacetica ATCC 3907...	544.0	[0..8]	[328..8]
gi\|119944101, gi... - gi\|119944101\|ref\|YP_941781.1\| delta-aminolevulinic acid dehydratase [Psychromonas ingrahamii 37], gi...	544.0	[0..6]	[328..9]
gi\|78045155, gi\|... - gi\|78045155\|ref\|YP_360053.1\| delta-aminolevulinic acid dehydratase [Carboxydothermus hydrogenoforman...	542.0	[0..3]	[328..1]
gi\|22294143, gi\|... - gi\|22297965\|ref\|NP_681212.1\| delta-aminolevulinic acid dehydratase [Thermosynechococcus elongatus BP...	541.0	[0..3]	[328..1]
gi\|22777750, gi\|... - gi\|23099521\|ref\|NP_692987.1\| delta-aminolevulinic acid dehydratase [Oceanobacillus iheyensis HTE831]...	538.0	[0..7]	[328..8]
gi\|53803043, gi\|... - gi\|53803043\|ref\|YP_115188.1\| delta-aminolevulinic acid dehydratase [Methylococcus capsulatus str. Ba...	536.0	[0..6]	[328..11]
gi\|89200306, gi\|... - gi\|89200306\|ref\|ZP_01179060.1\| Porphobilinogen synthase [Bacillus cereus subsp. cytotoxis NVH 391-98...	534.0	[0..8]	[328..8]
gi\|241903838, gi... - gi\|241903838\|ref\|ZP_04788555.1\| Porphobilinogen synthase [Thermoanaerobacter brockii subsp. finnii A... gi\|76589161, gi\|... - gi\|76795353\|ref\|ZP_00777726.1\| Porphobilinogen synthase [Thermoanaerobacter ethanolicus ATCC 33223],...	534.0	[0..3]	[327..1]

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Predicted Domain #1

Region A:
Residues: [1-329]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVDISSLLH AGYSNPLLRE WQGVRPITKS SLMYPIFISE IDDAKEAIDS MPNQFRWGVN  60
   61 RLEEFLGPLV KKGLRSVILF GVIESKKDYC GSMADSENGP VIKAVKEIRH LFPELVVACD 120
  121 VCLCEYTDHG HCGLLYEDGT INNAKSVERI AEVSGNYALA GAQIISPSDC MDGRVKAIKQ 180
  181 KLVELELSHK VCVISYSAKF ASGFFGPFRA AANGAPKFGD RSCYQLPCNA RGLAKRAILR 240
  241 DVREGADGIM VKPGTPYLDI LAMASKLADD LPIATYQVSG EFAIIHAAAA AGVFELKRHV 300
  301 METMDGFMRA GANIVLTYFT PELLEWLEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	135.0
Match:	1e51A
Description:	5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.67031204377352	bayes_pls_golite062009
porphobilinogen synthase activity	2.60788870678525	bayes_pls_golite062009
fructose-bisphosphate aldolase activity	0.877814788710295	bayes_pls_golite062009
binding	0.584966797881465	bayes_pls_golite062009
carbon-carbon lyase activity	0.55793298895297	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	0.487442544994915	bayes_pls_golite062009
transaldolase activity	0.184100272651834	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.132814423759102	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: