YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBPB2B2.12c
Organism:	Schizosaccharomyces pombe
Length:	713 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBPB2B2.12c.

Description	E-value	Query Range	Subject Range
gi\|62738905 - gi\|62738905\|pdb\|1Z45\|A Chain A, Crystal Structure Of The Gal10 Fusion Protein Galactose MutarotaseUD...	597.0	[0..4]	[691..10]
gi\|49653453 - gi\|49653453\|emb\|CAG85825.1\| DEHA2C02464p [Debaryomyces hansenii] gi\|50418541, gi\|... - gi\|50418541\|ref\|XP_457787.1\| hypothetical protein DEHA0C02838g [Debaryomyces hansenii CBS767], gi\|49...	588.0	[0..3]	[691..1]
gi\|68484682, gi\|... - gi\|68484682\|ref\|XP_713732.1\| hypothetical protein CaO19.11156 [Candida albicans SC5314], gi\|68484613... orf19.11156, orf... - GAL10 CGDID:CAL0000448 Assembly 19, Contig19-10186 (34326, 36353) CDS, translated using codon table ...	580.0	[0..3]	[690..1]
GAL10_KLULA - Bifunctional protein GAL10 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1... GAL10_KLULA, GAL... - (P09609) GAL10 bifunctional protein [Includes: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenas...	526.0	[0..1]	[692..1]
GAL10_PACTA - Bifunctional protein GAL10 OS=Pachysolen tannophilus GN=GAL10 PE=2 SV=1	524.0	[0..8]	[690..4]
gi\|2819, gi\|68389 - pir\|\|XUVKG UDPglucose 4-epimerase (EC 5.1.3.2) - yeast (Kluyveromyces marxianus var. lactis), gi\|281...	518.0	[0..1]	[692..1]
gi\|86142279, gi\|... - gi\|86142279\|ref\|ZP_01060789.1\| aldose 1-epimerase [Flavobacterium sp. MED217], gi\|85831031\|gb\|EAQ494... gi\|86142279, gi\|... - gi\|86142279\|ref\|ZP_01060789.1\| aldose 1-epimerase [Flavobacterium sp. MED217], gi\|85831031\|gb\|EAQ494...	395.0	[0..357]	[693..47]
gi\|15643051, gi\|... - gi\|4980780\|gb\|AAD35370.1\|AE001710_5 aldose 1-epimerase [Thermotoga maritima MSB8], gi\|15643051\|ref\|N... gi\|7445539 - pir\|\|H72395 probable aldose 1-epimerase (EC 5.1.3.3) - Thermotoga maritima (strain MSB8)	381.0	[0..346]	[693..1]

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Predicted Domain #1

Region A:
Residues: [1-713]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVQDEYILV TGGAGYIGSH TVIELINHGY KVIIVDNLCN SCYDAVARVE FIVRKSIKFF  60
   61 KLDLRDKEGL AQIFDTFKIK GVIHFAALKA VGESMKLPLE YYDNNICGTI TLLNVMREHR 120
  121 VKTVVFSSSA TVYGDATRFD NMIPIPESCP NDPTNPYGKT KYAIENIIKD LHTSDNTWRG 180
  181 AILRYFNPIG AHPSGLLGED PLGIPNNLLP FLAQVAIGRR EKLLVFGDDY DSHDGTPIRD 240
  241 YIHVVDLAKG HIAALNYLNK INNSEGMYRE WNLGTGKGSS VFDIYHAFCK EVGKDLPYEV 300
  301 VGRRTGDVLN LTASPNRANS ELKWKAELSI TDACRDLWKW TIENPFGFQI DNYKWKLFNT 360
  361 LGIMDYKNRL HTICFQDLEV SIANYGALVQ AVRYKGRNLV NGFNDFSRYK LKENPFFGAT 420
  421 IGRFANRIAN GQFEVDGHLY TLCKNENNKT TLHGGNNGFD KQFFLGPIAR QYEDYNTLEF 480
  481 ILVDKDGNNG FPSDLETLVK YTIKNNSLEI EYKSVIPEYS KLNVTAVNLT NHSYWNLASP 540
  541 NKTIDGTIIK STTNVYLKVN SETSLPTGDI VEWQNDITKP TKLDPNISFD NCFIVDREAS 600
  601 KFCLDTRKYS LKNIVEVIHP SVPVKLVVST TEPAFQLYTG DGNDICEFQS RSGFCVETGR 660
  661 FINALNNEKW SKQVILRKGE VYGARSKFSL YAQDLEENKH FLDSASYNSG EYY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	171.0
Match:	1z45A
Description:	Crystal structure of the gal10 fusion protein galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae complexed with NAD, UDP-glucose, and galactose
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aldose 1-epimerase activity	2.85100059704396	bayes_pls_golite062009
UDP-glucose 4-epimerase activity	2.13934644118967	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.03956654822048	bayes_pls_golite062009
nucleic acid binding	0.868888700854563	bayes_pls_golite062009
binding	0.835119783772935	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
DNA binding	0.790382977752475	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	0.65743456407889	bayes_pls_golite062009
transcription regulator activity	0.613310508772122	bayes_pls_golite062009
retinol dehydrogenase activity	0.48941662111046	bayes_pls_golite062009
NAD or NADH binding	0.44922383360529	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
transcription factor activity	0.11102650759187	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	0.0498966688564807	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: