YRC Public Data Repository - Protein Structure Prediction

Protein:	cek1
Organism:	Schizosaccharomyces pombe
Length:	1338 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cek1.

Description	E-value	Query Range	Subject Range
gi\|1853976 - gi\|1853976\|dbj\|BAA06551.1\| protein kinase [Schizosaccharomyces pombe]	902.0	[0..1]	[1297..1]
ppk18 - serine /threonine protein kinase Ppk18 PPK18_SCHPO - Serine/threonine-protein kinase ppk18 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ppk1...	614.0	[0..43]	[1336..23]
gi\|85091375 - gi\|85091375\|ref\|XP_958871.1\| hypothetical protein NCU07378 [Neurospora crassa OR74A] gi\|28920260, gi\|... - gi\|32414369\|ref\|XP_327664.1\| hypothetical protein [Neurospora crassa], gi\|28920260\|gb\|EAA29635.1\| hy...	538.0	[0..13]	[768..19]
gi\|39726347 - gi\|39726347\|gb\|AAR30116.1\| putative response regulator receiver RIM15p [Botryotinia fuckeliana] gi\|154296733, gi... - gi\|154296733\|ref\|XP_001548796.1\| conserved hypothetical protein [Botryotinia fuckeliana B05.10], gi\|...	537.0	[0..14]	[771..21]
gi\|39975017, gi\|... - gi\|39975017\|ref\|XP_368899.1\| hypothetical protein MGG_00345 [Magnaporthe grisea 70-15], gb\|EAA48687....	533.0	[0..15]	[768..51]
gi\|67901170, gi\|... - gi\|67901170\|ref\|XP_680841.1\| hypothetical protein AN7572.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	486.0	[0..19]	[751..35]
gi\|88181894, gi\|... - gi\|88181894\|gb\|EAQ89362.1\| hypothetical protein CHGG_05981 [Chaetomium globosum CBS 148.51], gi\|1161...	486.0	[0..17]	[776..15]
gi\|111066843 - gi\|111066843\|gb\|EAT87963.1\| hypothetical protein SNOG_04203 [Phaeosphaeria nodorum SN15]	478.0	[0..17]	[745..31]
gi\|115401772, gi... - gi\|115401772\|ref\|XP_001216474.1\| hypothetical protein ATEG_07853 [Aspergillus terreus NIH2624], gi\|1...	469.0	[0..20]	[776..36]
gi\|119195989, gi... - gi\|90307384\|gb\|EAS37015.1\| hypothetical protein CIMG_02369 [Coccidioides immitis RS], gi\|119195989\|r...	465.0	[0..18]	[770..38]

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Predicted Domain #1

Region A:
Residues: [1-263]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKHIKNEREE VFLEDDQAQH SQAELLSSKD ENLQPSIPLS PVAFELDFSG NFQFISDNSS  60
   61 ELLDIPKDKI IGHSVAEVLG TDGYNAFMRA VNCLLKDDSH SYHVRFQHSI NANHANQNYY 120
  121 TAKGDLPSDE KITKPFDAIG ILIRHPGSAI PAHTMWVVNP ATNSLGSVSP LVTKLLDVIG 180
  181 FGASLLDKYL CDLRTSYHKH NSLDALPLPT PEFCQICERE IQSWFFELHS KFCLSTSTYE 240
  241 SVVQAAQDSL LYFRSTLLEI QEG

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.06
Match:	1wa9A
Description:	Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [264-553]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKDSSLVPV YKNEPLIVDA DDYFFTDENK QTLSLCSFLS QVMYYLEVAI DITIPPVKII  60
   61 VNFDKVDSLR VQSPRSEKAT IELDNYNPSL ENCSSAVIAL WEDIKTAVDT KITGVLRLRN 120
  121 AIYYSERIRL EIDHHVQEII DDVVSNLVTN HSSTSLGHLE SKLAPSITFP DACDALEAEE 180
  181 CITRPGSATN TPQSDRSLDI NDLSRSSSYS RHLSHVSLSN PDFAIGSPMS QDSSNYSSPL 240
  241 HRRKASDSNF SDPRFDDLKY LSPNSSPRFV ASDGPNRPAS NGRSSLFSRG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [554-850]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RASNLGDVGL RLPSPSPRIH TIVPNSAPEH PSINDYKILK PISKGAFGSV YLAQKRTTGD  60
   61 YFAIKILKKS NMIAKNQVIN VRAERAILMS QGESPFVAKL YYTFQSKDYL YLVMEYLNGG 120
  121 DCGSLLKTMG VLDLDWIRTY IAETVLCLGD LHDRGIIHRD IKPENLLISQ NGHLKLTDFG 180
  181 LSRVGYMKRH RRKQSSSIPV LDLRDRSSAI SDLSLSTASS VLEAQSLITP ERPKRPSLNE 240
  241 KLLSLDGTSI RLAGQSFNYE NSAEDSPTAT NTPTSQVDES NIFRSTDSPR VQPFFEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.522879
Match:	1vzoA
Description:	The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
protein kinase activity	5.17195961442593	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
binding	2.10874590528357	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.684204466593894	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.196560862858137	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [851-916]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDPSKRFIGT PDYIAPEVIL GNPGIKASDW WSLGCVVFEF LFGYPPFNAE TPDQVFQNIL  60
   61 ARRINW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.522879
Match:	1fotA
Description:	cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [917-1204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAEVFTAESS VALDLIDRLL CMNPANRLGA NGVEEIKAHP FFKSVNWDTI LEEDPPFVPK  60
   61 PFSPEDTVYF DSRGLKGFDF SEYYNQPTVT EAQKLEEERP ASSIPQHVSG NRKGRLRSNT 120
  121 ISTPEFGSFT YRNLDFLNKA NRNTIQKLRK EHMAVKSAKT SVDDTFSQYM SRFKAKLSTS 180
  181 QSVGPVKSSR RASMADYEAS TTTRVQDITT DSIDSIDDFD SLKEGRMLSF FDNLALEDHK 240
  241 GVSSTMSASQ SQSSMHTALP DVTEGTSSDE HTTIQKGRID NLQAQSLT

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.19
Match:	1omwA
Description:	G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.52256824388179	bayes_pls_golite062009
protein binding	1.95763087285706	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.55414958698765	bayes_pls_golite062009
kinase activity	1.52393509273639	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.39413069155432	bayes_pls_golite062009
transferase activity	1.09391396934652	bayes_pls_golite062009
protein kinase activity	1.07426739991648	bayes_pls_golite062009
protein serine/threonine kinase activity	0.62326150960884	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [1205-1338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKRNAISYPG LFQLDRLQMI IPKDEIELAE ILKKIFPKLT LVLIDDPWSI LKKLLQNEQF  60
   61 NVVFLHFGND KVSSSRLMYS VRTSATINSR VPFVYICEDE TCIPTDLQSD GVLLKPITCE 120
  121 NIESCLRKLD VWHS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.69897
Match:	2ayxA
Description:	No description for 2ayxA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: