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View Structure Prediction Details

Protein: Cyp308a1-PA
Organism: Drosophila melanogaster
Length: 490 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cyp308a1-PA.

Description E-value Query
Range
Subject
Range
gi|76654204 - gi|76654204|ref|XP_584699.2| PREDICTED: similar to cytochrome P450, subfamily IIIA, polypeptide 4 is...
360.0 [0..4] [486..13]

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Predicted Domain #1
Region A:
Residues: [1-490]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPLVLFILL AATLLFWKWQ GNHWRRLGLE APFGWPLVGN MLDFALGRRS YGEIYQEIYT  60
   61 RNPGLKYVGF YRLFNEPAIL VRDQELLRQI LVGRNFADCA DNAVYVDHQR DVLASHNPFI 120
  121 ANGDRWRVLR ADLVPLFTPS RVRQTLPHVA RACQLLRDQV PLGRFEAKDL ATRYTLQVVA 180
  181 SAIFGLDAHC LGIHMRVAHE PSRWLEWLAP LFQPSVWSLL ETMSLLHTPR LGRLIGHRYV 240
  241 PLPLQHWFRE LVEARSGGDN LLQWLAESKR GLGKEELAGH ATTLLLEGYE TSAMLLAFAL 300
  301 YELALNEDAQ RRLHIELDEV AQRHAGNLID PVALGELRYS EAALLEALRL HPAMQALQKR 360
  361 CTKTFTLPDQ KSGASSELKV HLGTVLVLPV QAIHLDPALY PAPNQFRPER FLNQPPMGCR 420
  421 FLGFGAGPRM CPGMRLGLLQ TKAALTTLLQ DHCVQLADED QCRVEVSPLT FLTASRNGIW 480
  481 LSFKRRTRRY 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 92.69897
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
arachidonic acid monooxygenase activity 3.03830845324387 bayes_pls_golite062009
oxygen binding 2.77495508953933 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.60901411823382 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
demethylase activity 2.17116413461366 bayes_pls_golite062009
oxidoreductase activity 2.09151585300316 bayes_pls_golite062009
retinoid binding 1.91237853759594 bayes_pls_golite062009
isoprenoid binding 1.78853880472253 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 1.71732865382274 bayes_pls_golite062009
sterol 14-demethylase activity 1.68985995159863 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
retinoic acid binding 1.55035199545719 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 1.48500938886158 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
arachidonic acid epoxygenase activity 1.4220050618113 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.20113920678403 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.03699542179837 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 0.89030345144459 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 0.89030345144459 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 0.33710488712754 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.252480305257929 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 0.167565425989292 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle