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View Structure Prediction Details

Protein: B-H1-PA
Organism: Drosophila melanogaster
Length: 544 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for B-H1-PA.

Description E-value Query
Range
Subject
Range
gi|73999130 - gi|73999130|ref|XP_544097.2| PREDICTED: similar to chromodomain helicase DNA binding protein 7 isofo...
169.0 [0..5] [542..37]

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Predicted Domain #1
Region A:
Residues: [1-126]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDSMSILTQ TPSEPNAAHP QLHHHLSTLQ QQHHQHHLHY GLQPPAVAHS IHSTTTMSSG  60
   61 GSTTTASGIG KPNRSRFMIN DILAGSAAAA FYKQQQHHQQ LHHHNNNNNS GSSGGSSPAH 120
  121 SNNNNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [127-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INGDNCEASN VAGVGVLPSA LHHPQPHPPT HPHTHPHALM HPHGKLGHFP PTAGGNGLNV  60
   61 AQYAAAMQQH YAAAAAAAAA RNNAAAAAAA AAAAAAAGVA APPVDGGVDG GVGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [241-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APPAGGDLDD SSDYHEENED CDSGNMDDHS VCSNGGKDDD GNSVKSGSTS DMSGLSKKQR  60
   61 KARTAFTDHQ LQTLEKSFER QKYLSVQERQ ELAHKLDLSD CQVKTWYQNR RTKWKRQTAV 120
  121 GLELL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.30103
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.6809639302471 bayes_pls_golite062009
DNA binding 2.45264254102339 bayes_pls_golite062009
nucleic acid binding 2.32767577674158 bayes_pls_golite062009
binding 2.12643314274039 bayes_pls_golite062009
transcription factor activity 1.9610710007594 bayes_pls_golite062009
sequence-specific DNA binding 0.71974400731667 bayes_pls_golite062009
protein binding 0.57484570028668 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.328460252819506 bayes_pls_golite062009
transcription repressor activity 0.245215140763955 bayes_pls_golite062009
transcription activator activity 0.0177888191364471 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [366-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEAGNFAAFQ RLYGGSPYLG AWPYAAAAGA AHGATPHTNI DIYYRQAAAA AAMQKPLPYN  60
   61 LYAGVPSVGV GVGVGVGPAP FSHLSASSSL SSLSSYYQSA AAAASAANPG GPHPVAPPPS 120
  121 VGGGSPPSGL VKPIPAHSAS ASPPPRPPST PSPTLNPGSP PGRSVDSCSQ SDDEDQIQV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle