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View Structure Prediction Details

Protein: B-H2-PA
Organism: Drosophila melanogaster
Length: 645 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for B-H2-PA.

Description E-value Query
Range
Subject
Range
gi|113416398 - gi|113416398|ref|XP_001131587.1| PREDICTED: similar to gamma-aminobutyric acid A receptor, epsilon ...
149.0 [0..3] [633..57]

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Predicted Domain #1
Region A:
Residues: [1-129]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTMPPEMSA TTAAPVGSAP SATAHHPAAV GGGMPRPASP AVGSNTTTAT ATTATRSRFM  60
   61 ITDILAGAAA ASAAAAAAAA ALAAASSGGG RGSPTDSERE QSLVAQHHHH HQQQQQHHHH 120
  121 QQQQQQQQH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.15
Match: 2bvtA
Description: The structure of a modular endo-beta-1,4-mannanase from Cellulomonas fimi explains the product specificity of glycoside hydrolase family 26 mannanases.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.59063189683655 bayes_pls_golite062009
protein binding 1.40069187357924 bayes_pls_golite062009
ligand-gated channel activity 1.12064341222676 bayes_pls_golite062009
ligand-gated ion channel activity 1.12064341222676 bayes_pls_golite062009
gated channel activity 1.07009061846204 bayes_pls_golite062009
cation channel activity 1.06128106743399 bayes_pls_golite062009
ion channel activity 1.05202649422365 bayes_pls_golite062009
substrate-specific channel activity 1.0312639599585 bayes_pls_golite062009
channel activity 1.02722503832082 bayes_pls_golite062009
passive transmembrane transporter activity 1.02722503832082 bayes_pls_golite062009
cytoskeletal protein binding 0.558441391308061 bayes_pls_golite062009
cation transmembrane transporter activity 0.474611134490695 bayes_pls_golite062009
actin binding 0.471997325585296 bayes_pls_golite062009
voltage-gated cation channel activity 0.410123587360906 bayes_pls_golite062009
voltage-gated ion channel activity 0.35572857442145 bayes_pls_golite062009
voltage-gated channel activity 0.347698520417586 bayes_pls_golite062009
ion transmembrane transporter activity 0.302562057767319 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.23135104785491 bayes_pls_golite062009
potassium channel activity 0.111061655187583 bayes_pls_golite062009
voltage-gated potassium channel activity 0.0516610623213176 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [130-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQAALQQYIV QQQQLLRFER EREREREREH YRERHSPPGN NPYAHHPMPP HLLAHFPPAH  60
   61 YAVLQQQQQQ QQQQQHPHPH HLQLERERLE ALHRHGHGLT GDPAQHLSHL SHLSHQQHHP 120
  121 HLHHPMHDER SRSPLMLQQL GGNGGNNNNN NNNSSSASNN NNNNNNSASA NSNIISGNSS 180
  181 SSNNNNGSGN GNMLLGGPGS SISGDQASTI DDSDSD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [346-448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DCGGKDDDGD DSMKNGSSAN GDSSSHLSLS LSKKQRKART AFTDHQLQTL EKSFERQKYL  60
   61 SVQDRMELAN KLELSDCQVK TWYQNRRTKW KRQTAVGLEL LAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.522879
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [449-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGNYAAFQRL YGGATPYLSA WPYAAAAAAQ SPHGATPSAI DIYYRQAAAA AAMQKPSLPA  60
   61 SYRMYQSSIP PGMSLPGMPA PPPPGAAPML SGYYAAAAAA AASAGAQQQQ QQPPAASRSP 120
  121 ATSQSANSEA DCERTSSSSR QRLITPSPPL NPGSPPHRER INEEEDRERD EERDIERERE 180
  181 RERERDEDDE EELALEV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.979
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.94828015862607 bayes_pls_golite062009
catalytic activity 1.01989895762614 bayes_pls_golite062009
ligase activity 0.64896140325006 bayes_pls_golite062009
protein binding 0.458461360580002 bayes_pls_golite062009
acid-amino acid ligase activity 0.406646146913593 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle