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View Structure Prediction Details

Protein: FBpp0312045, Ork...
Organism: Drosophila melanogaster
Length: 1001 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0312045, Ork....

Description E-value Query
Range
Subject
Range
gi|78214281 - gi|78214281|gb|ABB36455.1| GH16237p [Drosophila melanogaster]
589.0 [0..1] [1001..1]

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Predicted Domain #1
Region A:
Residues: [1-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPNRWILLL IFYISYLMFG AAIYYHIEHG EEKISRAEQR KAQIAINEYL LEELGDKNTT  60
   61 TQDEILQRIS DYCDKPVTLP PTYDDTPYTW TFYHAFFFAF TVCSTVGYGN ISPTTFAGRM 120
  121 IMIAYSVIGI PVNGILFAGL GEYFGRTFEA IYRRYKKYKM STDMHYVPPQ LGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.0
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [174-431]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITTVVIALIP GIALFLLLPS WVFTYFENWP YSISLYYSYV TTTTIGFGDY VPTFGANQPK  60
   61 EFGGWFVVYQ IFVIVWFIFS LGYLVMIMTF ITRGLQSKKL AYLEQQLSSN LKATQNRIWS 120
  121 GVTKDVGYLR RMLNELYILK VKPVYTDVDI AYTLPRSNSC PDLSMYRVEP APIPSRKRAF 180
  181 SVCADMVAAQ REAGMVHANS DTELSKLDRE KTFETAEAYR QTTDLLAKVV NALATVKPPP 240
  241 AEQEDAALYG GYHGFSDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.39794
Match: 1lnqA
Description: Potassium channel-related protein MthK
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
inward rectifier potassium channel activity 5.0997110076666 bayes_pls_golite062009
potassium channel activity 3.07560078542081 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.98602674522518 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.96809690970616 bayes_pls_golite062009
voltage-gated potassium channel activity 2.89215814786806 bayes_pls_golite062009
cation transmembrane transporter activity 2.73807350248822 bayes_pls_golite062009
ligand-gated channel activity 2.72051922059922 bayes_pls_golite062009
ligand-gated ion channel activity 2.72051922059922 bayes_pls_golite062009
ion transmembrane transporter activity 2.67515190518646 bayes_pls_golite062009
voltage-gated cation channel activity 2.42997534485101 bayes_pls_golite062009
voltage-gated ion channel activity 2.36555310840994 bayes_pls_golite062009
voltage-gated channel activity 2.35294722733296 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.33083670641501 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.13014428099026 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.91774061209278 bayes_pls_golite062009
potassium ion transmembrane transporter activity 1.57069429249737 bayes_pls_golite062009
cation channel activity 1.43917477594689 bayes_pls_golite062009
channel activity 1.01956231306507 bayes_pls_golite062009
passive transmembrane transporter activity 1.01956231306507 bayes_pls_golite062009
substrate-specific channel activity 0.994513387627819 bayes_pls_golite062009
ion channel activity 0.990830355816173 bayes_pls_golite062009
gated channel activity 0.800384460449848 bayes_pls_golite062009
transporter activity 0.793769336118517 bayes_pls_golite062009
transmembrane transporter activity 0.635891484075352 bayes_pls_golite062009
substrate-specific transporter activity 0.555188550031886 bayes_pls_golite062009
signal transducer activity 0.293137523663314 bayes_pls_golite062009
molecular transducer activity 0.293137523663314 bayes_pls_golite062009
active transmembrane transporter activity 0.239024094835991 bayes_pls_golite062009
binding 0.144628283348863 bayes_pls_golite062009
G-protein coupled receptor activity 0.135469305070471 bayes_pls_golite062009
receptor activity 0.113048653187164 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [432-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QILASEWSFS TVNEFTSPRR PRARACSDFN LEAPRWQSER PLRSSHNEWT WSGDNQQIQE  60
   61 AFNQRYKGQQ RANGAANSTM VHLEPDALEE QLKKQSPGAG RVKKFSMPDG LRRLFPFQKK 120
  121 RPSQDLERKL SVVSVPEGVI SQQARSPLDY YSNTVTAASS QSYLRNGRGP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [602-788]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPFESNGSL ASGGGGLTNM GFQMEDGATP PSALGGGAYQ RKAAAGKRRR ESIYTQNQAP  60
   61 SARRGSMYPP TAHALAQMQM RRGSLATSGS GSAAMAAVAA RRGSLFPATA SASSLTSAPR 120
  121 RSSIFSVTSE KDMNVLEQTT IADLIRALEV VHTHAVLDEQ QQAAAAGGAA GGGGISRGSR 180
  181 KQRKMGN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [789-1001]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGLEPPQLPP ILSLFAGDQT RTLQAAAANR LYARRSTIVG ISPTGGAATA PAARSLLEPP  60
   61 PSYTERAANQ SQITAGPSNA PTVQSKFRRR FSVRPTALQI PPGQAPPPGA SLMEQSSQTA 120
  121 LQRRLSLRPS PLARELSPTS PPGGSGSALP AGAIDESGGT SAQRLLPLPA GTRPSTSSTH 180
  181 SPLSRIVQIS QAQRKSSMPS AAATGSSGAP AEK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle