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View Structure Prediction Details

Protein: alpha-Man-I-PJ, ...
Organism: Drosophila melanogaster
Length: 667 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for alpha-Man-I-PJ, ....

Description E-value Query
Range
Subject
Range
gi|2133635, gi|8... - gi|840754|emb|CAA57962.1| alpha 1,2 mannosidase [Drosophila melanogaster], pir||S60709 alpha 1,2 man...
763.0 [0..1] [667..1]

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Predicted Domain #1
Region A:
Residues: [1-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYRISPIGRK SNFHSREKCL IGLVLVTLCF LCFGGIFLLP DNFGSDRVLR VYKHFRKAGP  60
   61 EIFIPAPPLA AHAPHRSEDP HFIGDRQRLE QKIRAELGDM LDEPPAAGGG EPGQFQVLAQ 120
  121 QAQAPAPVAA LADQPLDQDE GHAAIPVLAA PVQGDNAASQ ASSHPQSSAQ QHNQQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [176-667]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPQLPLGGGG NDQAPDTLDA TLEERRQKVK EMMEHAWHNY KLYAWGKNEL RPLSQRPHSA  60
   61 SIFGSYDLGA TIVDGLDTLY IMGLEKEYRE GRDWIERKFS LDNISAELSV FETNIRFVGG 120
  121 MLTLYAFTGD PLYKEKAQHV ADKLLPAFQT PTGIPYALVN TKTGVAKNYG WASGGSSILS 180
  181 EFGTLHLEFA YLSDITGNPL YRERVQTIRQ VLKEIEKPKG LYPNFLNPKT GKWGQLHMSL 240
  241 GALGDSYYEY LLKAWLQSGQ TDEEAREMFD EAMLAILDKM VRTSPGGLTY VSDLKFDRLE 300
  301 HKMDHLACFS GGLFALGAAT RQNDYTDKYM EVGKGITNTC HESYIRAPTQ LGPEAFRFSE 360
  361 AVEARALRSQ EKYYILRPET FESYFVLWRL THDQKYRDWG WEAVLALEKH CRTAHGYCGL 420
  421 RNVYQQEPQK DDVQQSFFLA ETLKYLYLLF SDDSVLPLDE WVFNTEAHPL PIKGANAYYR 480
  481 QAPVTLPVSN AS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1nxcA
Description: Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mannosyl-oligosaccharide mannosidase activity 7.089685350864 bayes_pls_golite062009
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity 6.95179264736435 bayes_pls_golite062009
mannosidase activity 5.20286438265852 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 4.31319275372149 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 3.65589746311782 bayes_pls_golite062009
hydrolase activity 2.67964748309919 bayes_pls_golite062009
binding 1.49199031708525 bayes_pls_golite062009
catalytic activity 1.31873306707813 bayes_pls_golite062009
cation binding 0.362242764130218 bayes_pls_golite062009
metal ion binding 0.362242764130218 bayes_pls_golite062009
protein binding 0.36081692928767 bayes_pls_golite062009
ion binding 0.355220167272296 bayes_pls_golite062009
calcium ion binding 0.121126738064555 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle