YRC Public Data Repository - Protein Structure Prediction

Protein:	HP1b-PB, FBpp030...
Organism:	Drosophila melanogaster
Length:	240 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HP1b-PB, FBpp030....

Description	E-value	Query Range	Subject Range
gi\|16768330 - gi\|16768330\|gb\|AAL28384.1\| GM01918p [Drosophila melanogaster]	241.0	[0..1]	[240..1]
gi\|194203890, gi... - gi\|63146375\|gb\|AAY34033.1\| heterochromatin protein 1B [Drosophila simulans], gi\|195565857\|ref\|XP_002...	240.0	[0..1]	[240..1]
gi\|109067205 - gi\|109067205\|ref\|XP_001095397.1\| PREDICTED: similar to chromobox homolog 3 [Macaca mulatta]	191.0	[0..3]	[161..288]
gi\|114666540 - gi\|114666540\|ref\|XP_523820.2\| PREDICTED: similar to heterochromatin protein 1 beta [Pan troglodytes]	182.0	[0..10]	[158..191]
gi\|109488886 - gi\|109488886\|ref\|XP_340886.3\| PREDICTED: similar to Chromobox protein homolog 1 (Heterochromatin pro...	181.0	[0..10]	[158..591]
gi\|76645259 - gi\|76645259\|ref\|XP_873631.1\| PREDICTED: similar to Chromobox protein homolog 1 (Heterochromatin prot...	180.0	[0..10]	[158..127]
gi\|58568516 - gi\|58568516\|gb\|AAW78991.1\| GekBS145P [Gekko japonicus]	174.0	[0..3]	[161..29]
gi\|7416937 - gi\|7416937\|gb\|AAF62370.1\|AF136630_1 heterochromatin-like protein 1 [Homo sapiens]	172.0	[0..3]	[161..29]

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Predicted Domain #1

Region A:
Residues: [1-69]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEFSVERVE DKRTVNGRTE YYLKWKGYPR SENTWEPVEN LDCPDLIANF EESLKNNKKE  60
   61 TKKRLSTSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.522879
Match:	1knaA
Description:	Heterochromatin protein 1, HP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription repressor activity	4.08500855631983	bayes_pls_golite062009
transcription regulator activity	3.64390820819794	bayes_pls_golite062009
methylated histone residue binding	3.42338304360938	bayes_pls_golite062009
chromatin binding	3.1924157640698	bayes_pls_golite062009
binding	3.06758476214113	bayes_pls_golite062009
protein binding	2.66728689880621	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
histone binding	2.00388175060339	bayes_pls_golite062009
transcription activator activity	1.46529895769882	bayes_pls_golite062009
sequence-specific DNA binding	1.10020047862576	bayes_pls_golite062009
DNA-dependent ATPase activity	0.998957812785999	bayes_pls_golite062009
general transcriptional repressor activity	0.75184432495983	bayes_pls_golite062009
DNA helicase activity	0.726970683178132	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.494788451379878	bayes_pls_golite062009
transcription corepressor activity	0.294457188332415	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [70-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPESIRSKRK SFLEDDTEEQ KKLIGFERGL EASKILGATD SSGHLMFLMK WKGSDHADLV  60
   61 PAKLANTRCP QVVIQFYEER LTWHTGSGNG NGNTNSVNLG SSGGLGSVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.522879
Match:	1s4zA
Description:	HP1 chromo shadow domain in complex with PXVXL motif of CAF-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription repressor activity	4.08500855631983	bayes_pls_golite062009
transcription regulator activity	3.64390820819794	bayes_pls_golite062009
methylated histone residue binding	3.42338304360938	bayes_pls_golite062009
chromatin binding	3.1924157640698	bayes_pls_golite062009
binding	3.06758476214113	bayes_pls_golite062009
protein binding	2.66728689880621	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
histone binding	2.00388175060339	bayes_pls_golite062009
transcription activator activity	1.46529895769882	bayes_pls_golite062009
sequence-specific DNA binding	1.10020047862576	bayes_pls_golite062009
DNA-dependent ATPase activity	0.998957812785999	bayes_pls_golite062009
general transcriptional repressor activity	0.75184432495983	bayes_pls_golite062009
DNA helicase activity	0.726970683178132	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.494788451379878	bayes_pls_golite062009
transcription corepressor activity	0.294457188332415	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [179-240]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSGAGDDTAP GSVGTTGGGS NIDGGDEEDP EPASPIGSIN QDENIKPDES SELDNGQPDA  60
   61 DD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: