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View Structure Prediction Details

Protein: CG3108-PA
Organism: Drosophila melanogaster
Length: 1132 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG3108-PA.

Description E-value Query
Range
Subject
Range
gi|50756017 - gi|50756017|ref|XP_414978.1| PREDICTED: similar to Carboxypeptidase A2 precursor [Gallus gallus]
505.0 [0..622] [1117..68]

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Predicted Domain #1
Region A:
Residues: [1-227]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYNARSRGSA ANEGISPKRI VTIGSLLLVL GLNQVASMSL DRLALERNEL PADQQQQQQQ  60
   61 DVLVDNMKLT SIPSADSSDM YMLVPDTVAS QLEDTEHVNR NSIEADPESD PSGSSSSDML 120
  121 MLESDSSPAM QLVELPSDIT VAESQPETEH DTENDQQQPE SIEEHVVLMK PASQEAQLEQ 180
  181 TVDLATEAAP VPLNDELPED EESPAATESA VEELEKESEA AMDDQVP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [228-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EESEIQPEQV QPGEYQSESD GEQAETKPEI EAQPEVEAQP EAEAQPEAEP QLEVEPQPEV  60
   61 ESQPEVESQP EVEAQPEVEP QSEVESQPEA ESHSEPETQA EVEAQPEVES LPEAESQPEA 120
  121 ESQPEREPEV EAEKISDNEV DTTEASLMET LVEGIEDGLT AAMDNLVPEE LAEASDKQET 180
  181 ELESEDQQSP VTEAIEEQAV PEIEQEKEKE PEQIT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [443-564]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LADETEQDSA QPSNEEPVEI APEQHTEAEI APAKIPEEGK PEEEVQVEEE SKPVEESKPE  60
   61 EEIKQQEDAK PEEDDQNYAE TQPAVTEVKP EETPADIPVE IPAEVPAEIP AEIPAEVPAE 120
  121 IP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [565-719]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AESPAEIAAE VPAEIPAEIP AEIPAETPAE THAEIPADVP AQVVAEAPAE TPAETPAEVP  60
   61 AEIPSKVQDE IQSDSTQAEP QVEKEAQQPE KETKPLESSL LTTIIPMVMP QPQVPSQPLQ 120
  121 VQDSVLNYVN ASFMQQQPSE TDLPKTEEES PFNAH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.21
Match: 1h1kI
Description: THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [720-1132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRRYDGAQVW RIVVQTDKDK RMADELQSKY DGQLWKEVKQ EVDYLLKPQV LAAAERHIRA  60
   61 ANLSRIVLID NLQRVIEKEN PPAEKIAELQ NRKGHRLTWQ AYHRLEDIHG FIDYMAKTYP 120
  121 DICSTEIIGY SVEKRPLKIL KISNGNARNP GIWIDGGMHA REWISPATVT YIANQLVEGW 180
  181 EDLPEHMRSI NWYIHPVANP DGYEYSHTTD RLWRKNMRAH GRQCPGVDLN RNFGYKWGGK 240
  241 GTSASPCSQT YRGSKAFSEP ETFYISKFIS GFPRETFQAY LSFHSYGQYI LYPWGYDYQL 300
  301 TQDRADLDRV ARQAGTSITK STGVKYTVGS SATTLYPAAG GSDDWAKGIA GIKYAYTIEM 360
  361 GDTGRYGFVL PARFIQYNGK DGVTFADTVA RAIAQGRGKS VARNSSGSRR RGH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 137.0
Match: 1ayeA
Description: HUMAN PROCARBOXYPEPTIDASE A2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.786910294594 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.40766568731738 bayes_pls_golite062009
hydrolase activity 4.23257784904124 bayes_pls_golite062009
exopeptidase activity 3.28577934113028 bayes_pls_golite062009
metallopeptidase activity 2.76103081380105 bayes_pls_golite062009
carboxypeptidase activity 2.63658263814587 bayes_pls_golite062009
metalloexopeptidase activity 1.76058821499096 bayes_pls_golite062009
metallocarboxypeptidase activity 1.56827526553175 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
binding 1.13031326446259 bayes_pls_golite062009
endopeptidase activity 0.910234727191613 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.723243947871592 bayes_pls_golite062009
serine hydrolase activity 0.596149133958797 bayes_pls_golite062009
serine-type peptidase activity 0.578572340123331 bayes_pls_golite062009
nucleic acid binding 0.454707207494165 bayes_pls_golite062009
transcription regulator activity 0.273337363793137 bayes_pls_golite062009
DNA binding 0.115087846898245 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle