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View Structure Prediction Details

Protein: mav-PA
Organism: Drosophila melanogaster
Length: 701 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mav-PA.

Description E-value Query
Range
Subject
Range
gi|17944333 - gi|17944333|gb|AAL48059.1| RE69013p [Drosophila melanogaster]
758.0 [0..1] [689..1]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIDINPNLT PKKETAVWCD SFQHKCKVSN RTIKIFPSLL NKSNWIVSIL WHICVHHTIT  60
   61 IRNSKAREPP CKHPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [76-294]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITDNAEAKLT LVCSRSLKLY KIWFILILLM STQHQVSGHG IFRQTSSSKA VFSYYQPKEN  60
   61 ITFTNLQLQN LENEAKRLET NQHPIIRAKS TPKMGLKNVF ESFSKQSRDS IYNASSNKYS 120
  121 LINVSQSKNF PQLFNKKLSV QWINTVPIQS RQTRETRDIG LETKRHSKPS KRVDETRLKH 180
  181 LVLKGLGIKK LPDMRKVNIS QAEYSSKYIE YLSRLRSNQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [295-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKGNSYFNNF MGASFTRDLH FLSITTNGFN DISNKRLRHR RSLKKINRLN QNPKKHQNYG  60
   61 DLLRGEQDTM NILLHFPLTN AQDANFHHDK IDEA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [389-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVRLMLLYSS SLATNFRRGP GSRKNKISQI SGNDNIERHC NFGDVNLNQS NKNSSQQLTL  60
   61 KVYQLLSANR RRKITSRKIE FGNVGFQETR TQWIEFDVTK AVRSWLNKSH ENLGIEIQCD 120
  121 KCKSIGARIL SDFSPST

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [526-701]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPRSTASSDE HLNLMPVLNI IGHGTLNSQQ HGDADIHQIM LTNNRSDQYV HHRSNHDSTW  60
   61 RKDKWTNNCY KLHQRCCRNQ LDVAFKSIKG FEFILQPKVF DAGYCHGRCP PRHNPAHHHA 120
  121 LLQSLIWQED HKRAPRPCCT PSKLEMLEIL HVDENHSDKL KISTWSDMQV VECACS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.221849
Match: 1bmpA
Description: BONE MORPHOGENETIC PROTEIN-7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor serine/threonine kinase binding 2.59151978891498 bayes_pls_golite062009
transforming growth factor beta receptor binding 2.37742979972948 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 2.37742979972948 bayes_pls_golite062009
receptor binding 2.35731964024213 bayes_pls_golite062009
binding 1.94128368349087 bayes_pls_golite062009
protein binding 1.64946640536226 bayes_pls_golite062009
growth factor activity 1.46380647398443 bayes_pls_golite062009
growth factor binding 0.115424337995679 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 0.0947383314256207 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle