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View Structure Prediction Details

Protein: Ephrin-PC, Ephri...
Organism: Drosophila melanogaster
Length: 652 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ephrin-PC, Ephri....

Description E-value Query
Range
Subject
Range
gi|126002623, gi... - gi|54640158|gb|EAL29281.1| GA15017-PA [Drosophila pseudoobscura], gi|126002623|ref|XP_001382227.1| G...
567.0 [0..1] [620..1]

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Predicted Domain #1
Region A:
Residues: [1-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQERSKQLRL TVSWTQSKSQ IHDSCQRRSM LACKRRLTTS KVLEDSHPPV AFPNCKSHRH  60
   61 QQQKEKHKVQ LYSGKPLSIK LYVPGSIESI PKIRHKALTT TNKQQPAMHR KSKSKSKFQG 120
  121 FNNLKPLYSP SKRQPPEKHS SVLVEAGIES KASRHFVGKK RIKNRNCLLS SPQPSPMRCK 180
  181 MMIPFPKFGA TSFVTLLTLI CMETVLLSTM 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [211-336]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSCAKTFYMH WNTSNSIFRI DNTDHIIDVN KGNLAFEFDQ VHIICPVYEP GTFENETEKY  60
   61 IIYNVSKVEY ETCRITNADP RVIAICDKPQ KLMFFTITFR PFTPQPGGLE FLPGNDYYFI 120
  121 STSSKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.522879
Match: 1ikoP
Description: Ephrin-b2 ectodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ephrin receptor binding 2.36859280211986 bayes_pls_golite062009
substrate-specific transporter activity 2.36323002598215 bayes_pls_golite062009
transporter activity 2.349332206525 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.33073133834369 bayes_pls_golite062009
ion transmembrane transporter activity 2.32480642400158 bayes_pls_golite062009
transmembrane transporter activity 2.29776380543181 bayes_pls_golite062009
cation transmembrane transporter activity 2.29241843776882 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.06651640066545 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.62698854419438 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.56305555927578 bayes_pls_golite062009
binding 0.988564914693201 bayes_pls_golite062009
transmembrane-ephrin receptor activity 0.986157912102199 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.63330965564582 bayes_pls_golite062009
ephrin receptor activity 0.605684209141979 bayes_pls_golite062009
receptor activity 0.536491030734287 bayes_pls_golite062009
receptor binding 0.4653316685403 bayes_pls_golite062009
transmembrane receptor activity 0.416025501184058 bayes_pls_golite062009
protein binding 0.31459442397123 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.12460560872441 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [337-555]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLYRRIGGRC STNNMKVVFK VCCAPEDNNK TTALSNSKSV TDTGGAINVN IANNDESHVN  60
   61 SHGNNIAIGT NIGINGGQII GGPQSAGIPI NPLSGNNNIN GIPTTINSNI DQFNRIPIQP 120
  121 NIIGNHVGTN AVGTGIVGGG GIILTPGHAH GNINMLQPGR GGINGAYPGH HHIQTGIRIN 180
  181 NVPTQHNYPS HKGNANSNIN GNDDHHHYNK HPNEVVKNE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 1y0fB
Description: No description for 1y0fB was found.

Predicted Domain #4
Region A:
Residues: [556-652]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELTYNSGAAT SDGNIFALWI WILSIFPLLS IQSCHLSSYW ISASFLVSTI AILGIHYLIQ  60
   61 ITLQTTVQRY SPGMVEITAT SMNGMFDQNA GTIEYDR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle