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View Structure Prediction Details

Protein: aralar1-PC
Organism: Drosophila melanogaster
Length: 695 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for aralar1-PC.

Description E-value Query
Range
Subject
Range
gi|220955784, gi... - gi|220955784|gb|ACL90435.1| aralar1-PA [synthetic construct], gi|220946030|gb|ACL85558.1| aralar1-PA...
aralar1-PD, aral... - The gene aralar1 is referred to in FlyBase by the symbol Dmel\aralar1 (CG2139, FBgn0028646). It is a...
483.0 [0..15] [695..2]

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Predicted Domain #1
Region A:
Residues: [1-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMHIPFPFN WIPTLPVARC QESPSLLKRA GTEKLREVFL KYASIQKNGE HYMTSEDFVR  60
   61 KFLGLFSESA FNDESVRLLA NIADTSKDGL ISFSEFQAFE GLLCTPDALY RTAFQLFDRK 120
  121 GNGTVSYADF ADVVQKTELH SKIPFSLDGP FIKRYFGDKK QRLINYAEFT QLLH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.522879
Match: 1zuzA
Description: No description for 1zuzA was found.

Predicted functions:

Term Confidence Notes
calcium ion binding 3.79609619542776 bayes_pls_golite062009
binding 2.74623080162785 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.61874575467092 bayes_pls_golite062009
cytoskeletal protein binding 2.59226289545114 bayes_pls_golite062009
ion transmembrane transporter activity 2.57032504567157 bayes_pls_golite062009
cation transmembrane transporter activity 2.55650624542181 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37465721152046 bayes_pls_golite062009
structural molecule activity 2.02132683356917 bayes_pls_golite062009
potassium channel activity 1.89948827776974 bayes_pls_golite062009
motor activity 1.81368053536929 bayes_pls_golite062009
voltage-gated potassium channel activity 1.81135503818602 bayes_pls_golite062009
structural constituent of muscle 1.6840107470242 bayes_pls_golite062009
actin binding 1.50831300191117 bayes_pls_golite062009
cation channel activity 1.49312394054212 bayes_pls_golite062009
signal transducer activity 1.38521870126745 bayes_pls_golite062009
molecular transducer activity 1.38521870126745 bayes_pls_golite062009
ion binding 1.36376383271837 bayes_pls_golite062009
metal ion binding 1.34827363853601 bayes_pls_golite062009
cation binding 1.34827363853601 bayes_pls_golite062009
transcription regulator activity 1.22886396511326 bayes_pls_golite062009
protein binding 1.16246005294206 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
microfilament motor activity 1.0725773039399 bayes_pls_golite062009
channel activity 1.05847414989139 bayes_pls_golite062009
passive transmembrane transporter activity 1.05847414989139 bayes_pls_golite062009
ion channel activity 1.0369591011376 bayes_pls_golite062009
substrate-specific channel activity 1.03529144716694 bayes_pls_golite062009
voltage-gated cation channel activity 0.986621437232479 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
voltage-gated ion channel activity 0.910148857310729 bayes_pls_golite062009
voltage-gated channel activity 0.896351900356978 bayes_pls_golite062009
gated channel activity 0.855502499003241 bayes_pls_golite062009
tubulin binding 0.851404549871251 bayes_pls_golite062009
nucleic acid binding 0.849623084382492 bayes_pls_golite062009
actin-dependent ATPase activity 0.83859958498483 bayes_pls_golite062009
DNA binding 0.81633153359201 bayes_pls_golite062009
amine transmembrane transporter activity 0.717054504236607 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
microtubule binding 0.482216984478791 bayes_pls_golite062009
myosin binding 0.41761909113528 bayes_pls_golite062009
0.34446792626966 bayes_pls_golite062009
channel regulator activity 0.32809521759917 bayes_pls_golite062009
protein complex binding 0.278602833762221 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
myosin heavy chain binding 0.15875878144391 bayes_pls_golite062009
G-protein beta/gamma-subunit binding 0.13723868253862 bayes_pls_golite062009
transcription factor binding 0.02456682442567 bayes_pls_golite062009
actin filament binding 0.0239092123185181 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [175-335]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFHEEHAMEA FRSKDPAGTG FISPLDFQDI IVNVKRHLLT PGVRDNLVSV TEGHKVSFPY  60
   61 FIAFTSLLNN MELIKQVYLH ATEGSRTDMI TKDQILLAAQ TMSQITPLEI DILFHLAGAV 120
  121 HQAGRIDYSD LSNIAPEHYT KHMTHRLAEI KAVESPADRS A

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.36
Match: 2f2oA
Description: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [336-695]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIQVLESSYR FTLGSFAGAV GATVVYPIDL VKTRMQNQRA GSYIGEVAYR NSWDCFKKVV  60
   61 RHEGFMGLYR GLLPQLMGVA PEKAIKLTVN DLVRDKLTDK KGNIPTWAEV LAGGCAGASQ 120
  121 VVFTNPLEIV KIRLQVAGEI ASGSKIRAWS VVRELGLFGL YKGARACLLR DVPFSAIYFP 180
  181 TYAHTKAMMA DKDGYNHPLT LLAAGAIAGV PAASLVTPAD VIKTRLQVVA RSGQTTYTGV 240
  241 WDATKKIMAE EGPRAFWKGT AARVFRSSPQ FGVTLVTYEL LQRLFYVDFG GTQPKGSEAH 300
  301 KITTPLEQAA ASVTTENVDH IGGYRAAVPL LAGVESKFGL YLPRFGRGVT AASPSTATGS 360
  361 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.154902
Match: 1okcA
Description: structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle