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View Structure Prediction Details

Protein: Sry-delta-PA
Organism: Drosophila melanogaster
Length: 433 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Sry-delta-PA.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
661.0 [0..2] [432..2434]

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Predicted Domain #1
Region A:
Residues: [1-86]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTCFFCGAV DLSDTGSSSS MRYETLSAKV PSSQKTVSLV LTHLANCIQT QLDLKPGARL  60
   61 CPRCFQELSD YDTIMVNLMT TQKRLT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.992
Match: 1pzwA
Description: Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.84932768708444 bayes_pls_golite062009
DNA binding 3.45124926204188 bayes_pls_golite062009
nucleic acid binding 3.34875987514951 bayes_pls_golite062009
binding 2.8684204787273 bayes_pls_golite062009
transcription factor activity 2.74592237402384 bayes_pls_golite062009
transcription activator activity 1.45965791386122 bayes_pls_golite062009
sequence-specific DNA binding 1.44741411126911 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.32499836066598 bayes_pls_golite062009
protein binding 1.30321965120678 bayes_pls_golite062009
transcription factor binding 1.22761682002 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.1269808729848 bayes_pls_golite062009
structural constituent of ribosome 1.0478696280786 bayes_pls_golite062009
structural molecule activity 0.958501322313092 bayes_pls_golite062009
transcription cofactor activity 0.449959641856445 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.446369866668139 bayes_pls_golite062009
transcription repressor activity 0.199267983374872 bayes_pls_golite062009
catalytic activity 0.133319360419662 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [87-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQLKGALKSE FEVPESGEDI LVEEVEIPQS DVETDADAEA DALFVELVKD QEESDTEIKR  60
   61 EFVDEEEEED DDDDDEFICE DVDVGDSEA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [176-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYGKSSDGED RPTKKRVKQE CTTCGKVYNS WYQLQKHISE EHSKQPNHIC PICGVIRRDE  60
   61 EYLELHMNLH EGKTEKQCRY CPKSFSRPVN TLRHMRMHWD KKKYQCEKCG LRFSQDNLLY 120
  121 NHRLRHEAEE NPIICSICNV SFKSRKTFNH HTLIHKENRP RHYCSVCPKS FTERYTLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.522879
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [354-433]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHMKTHEGDV VYGVREEAPA DEQQVVEELH VDVDESEAAV TVIMSDNDEN SGFCLICNTN  60
   61 FENKKELEHH LQFDHDVVLK 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.06
Match: 1zu1A
Description: Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.47951889934838 bayes_pls_golite062009
nucleic acid binding 4.35187767955595 bayes_pls_golite062009
DNA binding 4.31051339571017 bayes_pls_golite062009
transcription factor activity 3.28758716579796 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.05542379535543 bayes_pls_golite062009
transcription activator activity 1.97757778483124 bayes_pls_golite062009
transcription repressor activity 1.44763794968807 bayes_pls_golite062009
sequence-specific DNA binding 1.26862497534835 bayes_pls_golite062009
chromatin binding 1.26688155139311 bayes_pls_golite062009
transcription factor binding 1.23738346570539 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.776754909146767 bayes_pls_golite062009
transcription cofactor activity 0.627794176881836 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle