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View Structure Prediction Details

Protein: Pli-PB, Pli-PA
Organism: Drosophila melanogaster
Length: 424 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pli-PB, Pli-PA.

Description E-value Query
Range
Subject
Range
CCDS1876.1_1 - null
tr|G3H131|G3H131... - Protein pellino-like 1 OS=Cricetulus griseus GN=I79_003854 PE=4 SV=1
PELI1 - pellino homolog 1 (Drosophila)
tr|M3XET5|M3XET5... - Pellino E3 ubiquitin protein ligase 1 OS=Felis catus GN=PELI1 PE=4 SV=1
834.0 [0..12] [424..1]

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Predicted Domain #1
Region A:
Residues: [1-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKRTDGTES PILAEDGGDG HDKPRLRYGE LVILGYNGYL PQGDRGRRRS KFVLHKRTEA  60
   61 SGVKRSKHYI VQSPQTSKAI LDANQHSISY TLSRNQAVIV EYKEDTETDM FQVGRSSESP 120
  121 IDFVVMDTLP GDKKDAKVMQ STISRFACRI LVNRCEPAKA RIFAAGFDSS RNIFLGEKAT 180
  181 KWQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [184-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNVEIDGLTT NGVLIMHPKG SFCGGNAKCG LWRECSVGGD VFSLRESRSA QQK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [237-333]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQPIYDECNI LQDGTLIDLC GATLLWRSAE GLQHSPTKHD LEKLIDAINA GRPQCPVGLN  60
   61 TLVIPRKVNI GDQVNQPYVY LNCGHVQGHH DWGQDEN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [334-424]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGARRCPMCL ELGPVVTLCM GLEPAFYVDV GAPTYAFNPC GHMATEKTVK YWANVEIPHG  60
   61 TNGFQAVCPF CATPLDGATG YIKLIFQDNL D

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.18
Match: 1e4uA
Description: Not-4 N-terminal RING finger domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.06923986676721 bayes_pls_golite062009
protein binding 1.48593945455888 bayes_pls_golite062009
small conjugating protein ligase activity 0.324292450240439 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.248014157054608 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle