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View Structure Prediction Details

Protein: pnt-PC
Organism: Drosophila melanogaster
Length: 623 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pnt-PC.

Description E-value Query
Range
Subject
Range
ETV5_MOUSE - ETS translocation variant 5 OS=Mus musculus GN=Etv5 PE=2 SV=1
258.0 [0..303] [622..144]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPSAFLVNA SIISAANALD SDKEQQLQEH LNQSHFTSSS SSSNSSNNNN CHTAPNYNMV  60
   61 LQSYENYPSY HLAQHHHHHH HHHSHPHHQL AQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.16
Match: 2odjA
Description: No description for 2odjA was found.

Predicted Domain #2
Region A:
Residues: [93-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTGLHSHHTM QQQLQQQQQS LLLQHPQQQQ QQHSHQSQQQ QQHGYGSSAQ LPHHRLSGGS  60
   61 TGSTTTTSSG SSSSGSSSSA SSQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.24
Match: 2apoA
Description: Crystal Structure of the Methanococcus jannaschii Cbf5 Nop10 Complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [176-357]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFANGSATAN NLVGALSSST AASLGLGYFN DMAPFVGDAN AYYTDSDVNF FSSGYNTSNT  60
   61 HDRINNSTPP QQQQSQQPTV NGSGSASSNN NNSMLPPAVQ QSNNENNNTS SSNTNNSSNN 120
  121 NNNSGGSNNS NAGSNNNNNN NNNINFMAAA AIFQHHLKEE PGTQNGNIGG YGGGSNSQND 180
  181 PT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.30103
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [358-446]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLSSYGLPAH LAAYGGGSGS GPTGGRSSGG GGDESDYHST ISAQDHQSQQ SSGGNGSGGA  60
   61 SGGSTGNSNG YLDSSSEFYG SYAGRNRFH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [447-623]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGYPPEFTPY DAQSFQSMGP QPTAMDQWGA AHAHQHPAAY MSTLGLDKGL LGGYTTQGGV  60
   61 PCFTGSGPIQ LWQFLLELLL DKTCQSFISW TGDGWEFKLT DPDEVARRWG IRKNKPKMNY 120
  121 EKLSRGLRYY YDKNIIHKTA GKRYVYRFVC DLQNLVGHTP EELVAKYDLK IEKKDVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.0
Match: 1gvjA
Description: ETS-1 DNA BINDING AND AUTOINHIBITORY DOMAINS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.69183445184264 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle