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View Structure Prediction Details

Protein: pnt-PC
Organism: Drosophila melanogaster
Length: 623 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pnt-PC.

Description E-value Query
Range
Subject
Range
ETV5_MOUSE - ETS translocation variant 5 OS=Mus musculus GN=Etv5 PE=2 SV=1
258.0 [0..303] [622..144]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPSAFLVNA SIISAANALD SDKEQQLQEH LNQSHFTSSS SSSNSSNNNN CHTAPNYNMV  60
   61 LQSYENYPSY HLAQHHHHHH HHHSHPHHQL AQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.16
Match: 2odjA
Description: No description for 2odjA was found.

Predicted Domain #2
Region A:
Residues: [93-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTGLHSHHTM QQQLQQQQQS LLLQHPQQQQ QQHSHQSQQQ QQHGYGSSAQ LPHHRLSGGS  60
   61 TGSTTTTSSG SSSSGSSSSA SSQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.24
Match: 2apoA
Description: Crystal Structure of the Methanococcus jannaschii Cbf5 Nop10 Complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [176-357]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFANGSATAN NLVGALSSST AASLGLGYFN DMAPFVGDAN AYYTDSDVNF FSSGYNTSNT  60
   61 HDRINNSTPP QQQQSQQPTV NGSGSASSNN NNSMLPPAVQ QSNNENNNTS SSNTNNSSNN 120
  121 NNNSGGSNNS NAGSNNNNNN NNNINFMAAA AIFQHHLKEE PGTQNGNIGG YGGGSNSQND 180
  181 PT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.30103
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [358-446]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLSSYGLPAH LAAYGGGSGS GPTGGRSSGG GGDESDYHST ISAQDHQSQQ SSGGNGSGGA  60
   61 SGGSTGNSNG YLDSSSEFYG SYAGRNRFH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [447-623]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGYPPEFTPY DAQSFQSMGP QPTAMDQWGA AHAHQHPAAY MSTLGLDKGL LGGYTTQGGV  60
   61 PCFTGSGPIQ LWQFLLELLL DKTCQSFISW TGDGWEFKLT DPDEVARRWG IRKNKPKMNY 120
  121 EKLSRGLRYY YDKNIIHKTA GKRYVYRFVC DLQNLVGHTP EELVAKYDLK IEKKDVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.0
Match: 1gvjA
Description: ETS-1 DNA BINDING AND AUTOINHIBITORY DOMAINS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.69183445184264 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle