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View Structure Prediction Details

Protein: sav-PA
Organism: Drosophila melanogaster
Length: 608 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sav-PA.

Description E-value Query
Range
Subject
Range
gi|125773671, gi... - gi|54637829|gb|EAL27231.1| GA17357-PA [Drosophila pseudoobscura], gi|125773671|ref|XP_001358094.1| G...
257.0 [0..1] [592..1]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYLTILLCN RKPTMLSRRN KEKSQHKEGV VGKYMKKDTP PDISVINVWS DQRAKKKSLQ  60
   61 RCASTSPSCE FHPRSSSTSR NTY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [84-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SCTDSQPDYY HARRAQSQMP LQQHSHSHPH SLPHPSHPHV RSHPPLPPHQ FRASSNQLSQ  60
   61 NSSNYVNFEQ IERMRRQQSS PLLQTTSSPA PGAGGFQRSY STTQRQHHPH LGGDSYDADQ 120
  121 GLLSASYANM LQLPQRPHSP AHYAVPPQQQ QH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [236-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQIHQQHAST PFGSTLRFDR AAMSIRERQP RYQPTSSPMQ QQQQQQQQQQ QQLQHTQLAA  60
   61 HLGGSYSSDS YPIYENPSRV ISMRATQSQR SESPIYSNTT ASSATLAVVP QHHHQGHLAV 120
  121 PSGSGGGSLS GSGRGGSSGS VRGASTSVQS LYVPPRTPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [395-536]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAVAGAGGSA NGSLQKVPSQ QSLTEPEELP LPPGWATQYT LHGRKYYIDH NAHTTHWNHP  60
   61 LEREGLPVGW RRVVSKMHGT YYENQYTGQS QRQHPCLTSY YVYTTSAEPP KAIRPEASLY 120
  121 APPTHTHNAL VPANPYLLEE IP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.09691
Match: 1tk7A
Description: NMR structure of WW domains (WW3-4) from Suppressor of Deltex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.80100608992875 bayes_pls_golite062009
binding 1.28256682962994 bayes_pls_golite062009
transcription activator activity 0.42234724730235 bayes_pls_golite062009
transcription factor binding 0.0726503146527797 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [537-608]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KWLAVYSEAD SSKDHLLQFN MFSLPELEGF DSMLVRLFKQ ELGTIVGFYE RYRRALILEK  60
   61 NRRAGQNQNQ NQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.30103
Match: 1zvdA
Description: Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain
Matching Structure (courtesy of the PDB):

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