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View Structure Prediction Details

Protein: lsn-PA
Organism: Drosophila melanogaster
Length: 254 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lsn-PA.

Description E-value Query
Range
Subject
Range
gi|54637888, gi|... - gi|54637888|gb|EAL27290.1| GA19743-PA [Drosophila pseudoobscura], gi|125773789|ref|XP_001358153.1| G...
335.0 [0..1] [252..1]
SNF8_RAT - Vacuolar-sorting protein SNF8 OS=Rattus norvegicus GN=Snf8 PE=1 SV=1
333.0 [0..2] [253..3]
gi|120577573, gi... - gi|147907030|ref|NP_001091233.1| hypothetical protein LOC100037026 [Xenopus laevis], gi|120577573|gb...
SNF8_MOUSE - Vacuolar-sorting protein SNF8 OS=Mus musculus GN=Snf8 PE=1 SV=1
331.0 [0..2] [253..3]
gi|208967456 - gi|208967456|dbj|BAG73742.1| SNF8, ESCRT-II complex subunit, homolog [synthetic construct]
SNF8 - SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
331.0 [0..2] [253..3]
gi|61855437, gi|... - gi|61855437|ref|XP_581943.1| PREDICTED: similar to EAP30 subunit of ELL complex isoform 1 [Bos tauru...
331.0 [0..2] [253..3]
gi|73966269 - gi|73966269|ref|XP_548183.2| PREDICTED: similar to EAP30 subunit of ELL complex isoform 1 [Canis fam...
330.0 [0..2] [253..3]
gi|50760739 - gi|50760739|ref|XP_418112.1| PREDICTED: similar to ELL complex EAP30 subunit [Gallus gallus]
327.0 [0..2] [252..3]
SNF8_XENTR - Vacuolar-sorting protein SNF8 OS=Xenopus tropicalis GN=snf8 PE=2 SV=1
326.0 [0..2] [251..3]

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Predicted Domain #1
Region A:
Residues: [1-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRRVGLGAI QQQKLAAEKY KDKGTDLQEN QLEQMTKQME VFRVKLEEFA MKHKEDIRKN  60
   61 SQFRKQFQEM CAAIGVDPLA TGKGFWSVLG MGDFYYELGV QVVEVCLAAN HKTGGLMELD 120
  121 DLRRRLIAAR GQSSVHQEIT KEDILMAAKK LSIFGNGFVV HKLGKGKYIV QSIPGELSME 180
  181 ETNILNAASN TEQGCVTQSQ LIKDLGWTDY RAQQSLDKVL GEGLCWIDKQ AGDEPAYWFP 240
  241 SLFPGRNAQT TAAT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 73.0
Match: 1u5tA
Description: Structure of the ESCRT-II endosomal trafficking complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.2723726467408 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
structure-specific DNA binding 0.750801486608713 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
signal transducer activity 0.574575108509588 bayes_pls_golite062009
molecular transducer activity 0.574575108509588 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009
small conjugating protein ligase activity 0.118016217031359 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle