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View Structure Prediction Details

Protein: cv-c-PA
Organism: Drosophila melanogaster
Length: 1017 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cv-c-PA.

Description E-value Query
Range
Subject
Range
gi|18447379 - gi|18447379|gb|AAL68254.1| RE02250p [Drosophila melanogaster]
738.0 [0..1] [1017..1]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRRMSITIR EYKFFRSFSQ KFENWPKRKA EALWRKMRER KIAEIEAVEA CKWLRAAGFP  60
   61 QYAQMYEDHQ FPIDLNNVAK DHTNLENDQL QSLYRRLCVL NRCATMRLDQ S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.221849
Match: 2h80A
Description: No description for 2h80A was found.

Predicted functions:

Term Confidence Notes
binding 1.98719702611774 bayes_pls_golite062009
protein binding 1.41065934507744 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKPQTPQQKE ESDDENFALS EHWTFQPHIR RWSRIGEMGL ELPPPGLLSL NVEKTESSSK  60
   61 ESSPDRFEED GAGITLVTPG CSKAGGIPND GSSLGEGSDS GRLRRSGSER IKDQAKALLR 120
  121 RVESIKSRRR KRQNRENVVI SGPTVLDLSQ FGQRSSLRKP DAVYSTPPSP 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [282-776]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SALSPMHTFP KAPFFGNDLK VPSHSDNFLS PNRSSPKRTP TTPRSMRTSP LHFFSSPMSQ  60
   61 LKEGKSDDSS SYYSDSQESS TGGKLSLRKP SKARRFLQRT GKVDDIGAHS DSECHQGRKL 120
  121 LIKDANSNTT EVKVKKLTRG GSLNLGKDPK KRDGFRSSSF RSRSTSRKEA KNDEDTAGAT 180
  181 TNGGSKRQPV VRWHSFQMEE RPNMIFRKCF SKKIEPLQED AGGMPFAAMS AGQLQIIRKL 240
  241 ALVTLTGHME RYCPSHRSGW NWELPKFIKK IKMPDYKDKK VFGVPLLMIL QRSGQTLPLA 300
  301 VRAAFRWLQL NALDQVGIFR KSGGKSRIMK LREQIEVTDS TAECMDVFDL QQAYDVADML 360
  361 KQYFRELPES LLTTKMSETF VAIFQHLPAE VRLDAVQCAV LLLPDENREI LYVLLEFLTI 420
  421 VAANSQQNQM TSNNLGVCLA QSIFHSSIST GSASVSASPR RKGKGSGMPD MKELAEAKAS 480
  481 HECLSFMIEH YKQIY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.522879
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Rho GTPase activator activity 1.80530939069504 bayes_pls_golite062009
binding 1.45166365519386 bayes_pls_golite062009
epidermal growth factor receptor binding 1.03934535504406 bayes_pls_golite062009
molecular adaptor activity 0.58947294551094 bayes_pls_golite062009
protein binding 0.572527324734966 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.52889761132084 bayes_pls_golite062009
Rac GTPase activator activity 0.50993873602409 bayes_pls_golite062009
insulin receptor binding 0.28737567192381 bayes_pls_golite062009
receptor binding 0.24683439420295 bayes_pls_golite062009
protein binding, bridging 0.0904972759345899 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [777-1017]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAAKEKLSKC NFSYMEESKP LPLEALGEGM QFHNWRGYLY ECTSATIKEG REKTRGWFSI  60
   61 NSLNDSSVDI AYKKVGDGHP LRLWRCSTEI EGPPKEVLEF VIKQRASWDT NLLQCQTVKK 120
  121 LDDRTEIYQY ALDGQLTTDF CVLRSWQTDL PRGACVIVET SIDHAKAKPL FGAVRGVVLA 180
  181 SRYLIEPCGS GRSRVMHLAR VDVKGKTPEW YNKNYGHICS HYLSRIRLAF KHVADGPESK 240
  241 V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.69897
Match: 2psoA
Description: No description for 2psoA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle