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View Structure Prediction Details

Protein: CG12267-PA, FBpp...
Organism: Drosophila melanogaster
Length: 522 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG12267-PA, FBpp....

Description E-value Query
Range		 Subject
Range
RPC3_BOVIN - DNA-directed RNA polymerase III subunit RPC3 OS=Bos taurus GN=POLR3C PE=2 SV=1
 609.0 [0..1] [509..1]

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Predicted Domain #1
Region A:
Residues: [1-135] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADYSHLSS AILEQCFGKV VQAVADCLFS ATTRTLGQIT SATKLSRKEV AFALAVLVKF  60
   61 RLVDFAASKA NPFLAEYALR REDVLCLLRY PRYVHLVQTK YGNVGASISE ELINSGSDTA 120
  121 TGILLKCLAE NENKA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.31
Match: 1sfxA
Description: X-ray crystal structure of putative HTH transcription regulator from Archaeoglobus fulgidus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.23858959608048 bayes_pls_golite062009
DNA binding 4.78517210147551 bayes_pls_golite062009
nucleic acid binding 4.72059012764202 bayes_pls_golite062009
DNA-directed RNA polymerase activity 4.34522534923857 bayes_pls_golite062009
RNA polymerase activity 4.34522534923857 bayes_pls_golite062009
transcription factor activity 4.02736190679869 bayes_pls_golite062009
binding 3.37660003833383 bayes_pls_golite062009
nucleotidyltransferase activity 2.82260867370675 bayes_pls_golite062009
sequence-specific DNA binding 2.21432668306508 bayes_pls_golite062009
transferase activity 2.21031006146354 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.16473039675898 bayes_pls_golite062009
transcription activator activity 2.13702350917359 bayes_pls_golite062009
transcription repressor activity 1.9708626903609 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.50332889556988 bayes_pls_golite062009
transcription factor binding 0.752335897765285 bayes_pls_golite062009
protein binding 0.726445167461826 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.451714629708561 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [136-316] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESPESYRNTF LEMITDHYII KRPELLVGDD QDENVPKFET NECDFFRHPN IDLQLLAKIQ  60
   61 KGEATLAEAR DSHMVWHLNH DRFHQDFRDT IMVDAIERKL GENAAECFKF ILKIMYNTTD 120
  121 PWERKLSNQI TFVEIKQAIE RKSNNLDLMK YLDQYISLLT EDSLGFFRRV GDMGGGVYVV 180
  181 D

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 38.522879
Match: PF05645.4
Description: No description for PF05645.4 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [317-437] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHAFESLAF ACVECVITER FGSKAARIFR VIRCKKYIEQ EDLQKEAMIP SKEAKSLAYN  60
   61 LFQEQFIHVK IIKKPGGGSN GPAKAFYLFQ VKEKDTVRML LDASYKSLYN TIERSNFEKN 120
  121 E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1q1hA
Description: An extended winged helix domain in general transcription factor E/IIE alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
RNA polymerase activity 4.38040357248614 bayes_pls_golite062009
DNA-directed RNA polymerase activity 4.38040357248614 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
nucleotidyltransferase activity 2.80876790343695 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
transferase activity 2.17455387041569 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.13327310661537 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.461477365615935 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [438-522] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKGLIEKSQR LDSIVEAMKE RGETDEYIAE IVETFTPPEC EILNKVKNRI KTLSKAELTL  60
   61 DDTIFLLQMY QHHCTTLPTG IRKFK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle