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View Structure Prediction Details

Protein: by-PC, by-PA, by-PD
Organism: Drosophila melanogaster
Length: 720 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for by-PC, by-PA, by-PD.

Description E-value Query
Range
Subject
Range
gi|63803 - gi|63803|emb|CAA46992.1| tensin [Gallus gallus]
338.0 [0..457] [716..3]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTPYEESAA AADHKYQYQY TAANNNNNYY KNYNVNGNGQ ANGNGNLSGI GNGNGIGNGN  60
   61 GYGIPYHARE NSLPFSYGIA KTSTPLRKTP TPTRVDSFLD FDFGPTNT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [109-194]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVNSNSSSNN GGTGDMIKPP TRLTSPLLVR KTLGNAVSPT SSTNTNTIAN TYHYTSSSAT  60
   61 PTPVRDNFEQ LLRERREKVY NEYRNL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [195-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRESSGERAR VAPAPPQRQY YPSDGYGIGL KNDSNGTLYR KSPSSNGKST KYNYDFEFNL  60
   61 NLDDVRPEPT PYTTRNIHFE DLRLDQDVPD GVVNRRTMER NYHTINSLET TH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [307-373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRQQLEPLEQ LGAVYGQNHM EETLTRTRRD LSASTSTSKS TSPLPAIGVP AIAPASPIYA  60
   61 TSTKRVS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [374-446]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPNTNGQQQM TPSPTSRPET PAFPVTPRTP FGASSSSSAS LAPTTQLPPE SIYQTGPRRG  60
   61 VPPALQPLEV SAD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.221849
Match: 1g83A
Description: Fyn proto-oncogene tyrosine kinase, SH3 domain; Tyrosine kinase Fyn
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [447-664]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVQFARSSSQ FWYKPNLTRE DAIALLASAQ PGTFLVRDST TYKDSYGLVV RVSQPPPGSQ  60
   61 ELVRHFLIEP TKGGVHLKGC DDEPVFTSLS ALVFEHSISQ LALPCLLRLP DRDIVPPVRA 120
  121 TTPAQQHLLA HGAATNVLWL YSCDTESLTG NEAIRKAIRQ MYGQQPLPQP TEVHFKVSSQ 180
  181 GITLTDNTRK KFFRKHYKAD VISHCAIDPE NRMWTSEG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.522879
Match: 1m61A
Description: Tyrosine-protein kinase zap-70
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.28887512041698 bayes_pls_golite062009
signal transducer activity 2.07133863841547 bayes_pls_golite062009
molecular transducer activity 2.07133863841547 bayes_pls_golite062009
protein binding 2.04603930248857 bayes_pls_golite062009
molecular adaptor activity 0.93584922485564 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.72842829338771 bayes_pls_golite062009
receptor binding 0.49361386378291 bayes_pls_golite062009
protein binding, bridging 0.192710997278041 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [665-720]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESDKKTIFAF VARRSHSSTD NQCHVFCDLS VSQPAAAIVS FANRTLPTEK LRNYVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.045757
Match: 2gjyA
Description: No description for 2gjyA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle