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View Structure Prediction Details

Protein: HP1e-PA
Organism: Drosophila melanogaster
Length: 174 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HP1e-PA.

Description E-value Query
Range
Subject
Range
gi|109067205 - gi|109067205|ref|XP_001095397.1| PREDICTED: similar to chromobox homolog 3 [Macaca mulatta]
186.0 [0..10] [171..272]

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Predicted Domain #1
Region A:
Residues: [1-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSDADGGET VSNFSENSTD FEETEEYIVE RILDRRHYMG QLQYLVKWLD YSDEDNTWES  60
   61 AADLDCHSLI DSIESQKSLK RGQELNNQYE TKAKRLKIDP CLVVDSPFNH GFTAQEILKG 120
  121 AKNNGEISFL IRFWHLDQPQ VVPSGIAYVE IPQMVLKFYE NHCNFHDYLN NYIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.221849
Match: 2b2tA
Description: Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and phosphothreonine 3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
methylated histone residue binding 3.42338304360938 bayes_pls_golite062009
chromatin binding 3.1924157640698 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
protein binding 2.66728689880621 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
histone binding 2.00388175060339 bayes_pls_golite062009
transcription activator activity 1.46529895769882 bayes_pls_golite062009
sequence-specific DNA binding 1.10020047862576 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle