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View Structure Prediction Details

Protein: Ada-PA
Organism: Drosophila melanogaster
Length: 337 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ada-PA.

Description E-value Query
Range
Subject
Range
ADE_ACIAD - Adenine deaminase OS=Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) GN=ACIAD1245 PE=3 SV=1
253.0 [0..3] [328..5]

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Predicted Domain #1
Region A:
Residues: [1-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQFLKGLPK VELHAHLNGS LGIKSLCDLG ERLYGTSCKD FLKLCAHFSR FEKDMDACFE  60
   61 KFAFVHELTS TREGLRFATE LAIRDFAEDN VQYVEMRTTP KANENYSRRD YLQIVIDAIK 120
  121 AASETYPEIT VKLLPSINRA EPVDVAEETV SLAVELARAH PNLILGIDLS GNPGKGRFSD 180
  181 FAPILAQARD KGLKLAIHCA EIENPSEVKE MLHFGMSRCG HGTFLTPEDI GQLKQRNIAI 240
  241 ECCLTSNVKS GTVPSLEEHH LKRIMEADAP KVICTDDSGV FDTTLTKEFL IAAETFGLTR 300
  301 EQCIDLTLEA VHHSFASEQE QIQMADRVGN YADILVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.0
Match: 1ndvA
Description: Crystal Structure of Adenosine Deaminase complexed with FR117016
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
purine nucleoside binding 5.77008212157543 bayes_pls_golite062009
adenosine deaminase activity 4.58148305437166 bayes_pls_golite062009
adenine deaminase activity 3.70002828902508 bayes_pls_golite062009
hydrolase activity 3.62199995345412 bayes_pls_golite062009
dihydropyrimidinase activity 3.41635858763209 bayes_pls_golite062009
deaminase activity 1.79186203771221 bayes_pls_golite062009
catalytic activity 1.70199291046899 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.60895003474033 bayes_pls_golite062009
binding 1.20793368650496 bayes_pls_golite062009
protein binding 0.928500526896831 bayes_pls_golite062009
guanine deaminase activity 0.861706835095856 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 0.787370269329878 bayes_pls_golite062009
nucleic acid binding 0.629962267754185 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.573107361273483 bayes_pls_golite062009
transcription regulator activity 0.530552339840648 bayes_pls_golite062009
DNA binding 0.462348875991261 bayes_pls_golite062009
glycosaminoglycan binding 0.408989331337656 bayes_pls_golite062009
peptidase activity 0.356051335471361 bayes_pls_golite062009
dihydroorotase activity 0.203044795244555 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle