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View Structure Prediction Details

Protein: Mlp84B-PA, Mlp84B-PB
Organism: Drosophila melanogaster
Length: 495 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Mlp84B-PA, Mlp84B-PB.

Description E-value Query
Range
Subject
Range
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
627.0 [0..2] [494..717]

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Predicted Domain #1
Region A:
Residues: [1-205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSFQPIEAP KCPRCGKSVY AAEERLAGGY VFHKNCFKCG MCNKSLDSTN CTEHERELYC  60
   61 KTCHGRKFGP KGYGFGTGAG TLSMDNGSQF LRENGDVPSV RNGARLEPRA IARAPEGEGC 120
  121 PRCGGYVYAA EQMLARGRSW HKECFKCGTC KKGLDSILCC EAPDKNIYCK GCYAKKFGPK 180
  181 GYGYGQGGGA LQSDCYAHDD GAPQI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.522879
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #2
Region A:
Residues: [206-348]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAAIDVDKIQ ARPGEGCPRC GGVVYAAEQK LSKGREWHKK CFNCKDCHKT LDSINASDGP  60
   61 DRDVYCRTCY GKKWGPHGYG FACGSGFLQT DGLTEDQISA NRPFYNPDTT SIKARDGEGC 120
  121 PRCGGAVFAA EQQLSKGKVW HKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 1ubdC
Description: Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [349-495]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CYNCADCHRP LDSVLACDGP DGDIHCRACY GKLFGPKGFG YGHAPTLVST SGESTIQFPD  60
   61 GRPLAGPKTS GGCPRCGFAV FAAEQMISKT RIWHKRCFYC SDCRKSLDST NLNDGPDGDI 120
  121 YCRACYGRNF GPKGVGYGLG AGALTTF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.39794
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.10743787485868 bayes_pls_golite062009
transcription regulator activity 2.9286072149962 bayes_pls_golite062009
DNA binding 2.91902554182176 bayes_pls_golite062009
nucleic acid binding 2.84809232393523 bayes_pls_golite062009
cytoskeletal protein binding 2.22104591928521 bayes_pls_golite062009
transcription activator activity 2.18185767124518 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
transcription factor activity 2.01262882344347 bayes_pls_golite062009
sequence-specific DNA binding 1.39839669257043 bayes_pls_golite062009
chromatin binding 1.24664529610294 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.11260773303318 bayes_pls_golite062009
structure-specific DNA binding 0.93314267845352 bayes_pls_golite062009
tubulin binding 0.744315484113484 bayes_pls_golite062009
transcription repressor activity 0.587070313263399 bayes_pls_golite062009
microtubule binding 0.576452165256057 bayes_pls_golite062009
metal ion binding 0.571385009230828 bayes_pls_golite062009
cation binding 0.571385009230828 bayes_pls_golite062009
ion binding 0.564805140353876 bayes_pls_golite062009
double-stranded DNA binding 0.53991278722671 bayes_pls_golite062009
transition metal ion binding 0.495045338513967 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.47431986827149 bayes_pls_golite062009
transcription factor binding 0.44682958253968 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle