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View Structure Prediction Details

Protein: bcd-PG
Organism: Drosophila melanogaster
Length: 494 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for bcd-PG.

Description E-value Query
Range
Subject
Range
gi|72250, gi|311722 - pir||WJFFBC homeotic protein bicoid - fruit fly (Drosophila melanogaster), gi|311722|emb|CAA30720.1...
203.0 [0..1] [494..1]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPPPDQNF YHHPLPHTHT HPHPHSHPHP HSHPHPHHQH PQLQLPPQFR NPFDLLFDER  60
   61 TGAINYNYIR PYLPNQMPKP DVFP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [85-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEELPDSLVM RRPRRTRTTF TSSQIAELEQ HFLQGRYLTA PRLADLSAKL ALGTAQVKIW  60
   61 FKNRRRRHKI QSDQHK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1zq3P
Description: NMR Solution Structure of the Bicoid Homeodomain Bound to the Consensus DNA Binding Site TAATCC
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
transcription repressor activity 3.29590968570638 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription corepressor activity 1.28746845122519 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [161-320]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQSYEGMPLS PGMKQSDGDP PSLQTLSLGG GATPNALTPS PTPSTPTAHM TEHYSESFNA  60
   61 YYNYNGGHNH AQANRHMHMQ YPSGGGPGPG STNVNGGQFF QQQQVHNHQQ QLHHQGNHVP 120
  121 HQMQQQQQQA QQQQYHHFDF QQKQASACRV LVKDEPEADY 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [321-494]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFNSSYYMRS GMSGATASAS AVARGAASPG SEVYEPLTPK NDESPSLCGI GIGGPCAIAV  60
   61 GETEAADDMD DGTSKKTTLQ ILEPLKGLDK SCDDGSSDDM STGIRALAGT GNRGAAFAKF 120
  121 GKPSPPQGPQ PPLGMGGVAM GESNQYQCTM DTIMQAYNPH RNAAGNSQFA YCFN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle