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View Structure Prediction Details

Protein: bcd-PG
Organism: Drosophila melanogaster
Length: 494 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for bcd-PG.

Description E-value Query
Range
Subject
Range
gi|72250, gi|311722 - pir||WJFFBC homeotic protein bicoid - fruit fly (Drosophila melanogaster), gi|311722|emb|CAA30720.1...
203.0 [0..1] [494..1]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPPPDQNF YHHPLPHTHT HPHPHSHPHP HSHPHPHHQH PQLQLPPQFR NPFDLLFDER  60
   61 TGAINYNYIR PYLPNQMPKP DVFP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [85-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEELPDSLVM RRPRRTRTTF TSSQIAELEQ HFLQGRYLTA PRLADLSAKL ALGTAQVKIW  60
   61 FKNRRRRHKI QSDQHK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1zq3P
Description: NMR Solution Structure of the Bicoid Homeodomain Bound to the Consensus DNA Binding Site TAATCC
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
transcription repressor activity 3.29590968570638 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription corepressor activity 1.28746845122519 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [161-320]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQSYEGMPLS PGMKQSDGDP PSLQTLSLGG GATPNALTPS PTPSTPTAHM TEHYSESFNA  60
   61 YYNYNGGHNH AQANRHMHMQ YPSGGGPGPG STNVNGGQFF QQQQVHNHQQ QLHHQGNHVP 120
  121 HQMQQQQQQA QQQQYHHFDF QQKQASACRV LVKDEPEADY 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [321-494]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFNSSYYMRS GMSGATASAS AVARGAASPG SEVYEPLTPK NDESPSLCGI GIGGPCAIAV  60
   61 GETEAADDMD DGTSKKTTLQ ILEPLKGLDK SCDDGSSDDM STGIRALAGT GNRGAAFAKF 120
  121 GKPSPPQGPQ PPLGMGGVAM GESNQYQCTM DTIMQAYNPH RNAAGNSQFA YCFN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle