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View Structure Prediction Details

Protein: noi-PA
Organism: Drosophila melanogaster
Length: 503 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for noi-PA.

Description E-value Query
Range
Subject
Range
gi|54311245, gi|... - gi|54311245|gb|AAH84823.1| LOC495359 protein [Xenopus laevis], gi|148227146|ref|NP_001088491.1| hypo...
701.0 [0..1] [503..1]

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Predicted Domain #1
Region A:
Residues: [1-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METLLEQQRR LHEERERLVK LMVDEHATKK PGEKERIHSE HRLKYLMELH HNSTSQLRDL  60
   61 YEDKDNERKA EIAALSGPNE FNEFYARLKQ IKQFYKSHPA EVSVPLSVEF DEMIRVYNNP 120
  121 DDMSALVEFT DEEGGGRYLD LNECYELYLN LRSVEKLDYI TYLMSFDHVF DIPRERKNRE 180
  181 YRIYIETLND YLHHFILRIQ PLLDLEGELL KVELDFQRQW LMGTFPGFSI K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [232-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETESALANTG AHLDLSAFSS WEELASLGLD RLKSALVALG LKCGGTLEER AQRLFSTKGK  60
   61 STLDPALMAK KPSAK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.697 0.080 nuclear mRNA splicing, via spliceosome a.65.1 Annexin
View Download 0.477 0.039 nuclear mRNA splicing, via spliceosome a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.500 0.025 nuclear mRNA splicing, via spliceosome a.64.1 Saposin
View Download 0.430 0.007 nuclear mRNA splicing, via spliceosome a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.559 N/A N/A a.65.1 Annexin

Predicted Domain #3
Region A:
Residues: [307-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TASAQSREHE RHKEIAQLEA LLYKYADLLS EQRAATKENV QRKQARTGGE RDDSDVEASE  60
   61 SDNEDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [373-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDADDVPYNP KNLPLGWDGK PIPYWLYKLH GLNISYNCEI CGNFTYKGPK AFQRHFAEWR  60
   61 HAHGMRCLGI PNTAHFANVT QIEDAITLWE KLKSQKQSER WVADQEEEFE DSLGNVVNRK 120
  121 TFEDLKRQGL L

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.05
Match: 1zr9A
Description: Solution Structure of a Human C2H2-type Zinc Finger Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.37529385176635 bayes_pls_golite062009
DNA binding 3.3049326844117 bayes_pls_golite062009
nucleic acid binding 3.24981360535232 bayes_pls_golite062009
snRNA binding 3.16782731106334 bayes_pls_golite062009
RNA binding 3.11293528368816 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
U1 snRNA binding 2.86343975521155 bayes_pls_golite062009
transcription factor activity 2.44389510173662 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.57041104288348 bayes_pls_golite062009
mRNA binding 1.28525296322454 bayes_pls_golite062009
transcription activator activity 1.20323819132961 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
sequence-specific DNA binding 0.732558534458316 bayes_pls_golite062009
transcription repressor activity 0.686318575498149 bayes_pls_golite062009
chromatin binding 0.626365497850853 bayes_pls_golite062009
transcription factor binding 0.515821187939278 bayes_pls_golite062009
cytoskeletal protein binding 0.380243728411498 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.200483461579207 bayes_pls_golite062009
tubulin binding 0.151955152284472 bayes_pls_golite062009
transcription cofactor activity 0.113925660147477 bayes_pls_golite062009
structure-specific DNA binding 0.0855506955761403 bayes_pls_golite062009
microtubule binding 0.05082413668213 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle