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View Structure Prediction Details

Protein: Karybeta3-PA, FB...
Organism: Drosophila melanogaster
Length: 1105 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Karybeta3-PA, FB....

Description E-value Query
Range
Subject
Range
gi|24797086, gi|... - gi|24797086|ref|NP_002262.3| importin 5 [Homo sapiens], gi|119629382|gb|EAX08977.1| RAN binding prot...
586.0 [0..4] [1099..25]

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Predicted Domain #1
Region A:
Residues: [1-821]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAADQAHFQQ LLASLLSTDN DVRQQAEEAY NNLSRELKVT HLLGNIQNGQ QSEEARQMAA  60
   61 VLLRRLFTTE FFDFYKGLPA ESQNQLLQQI LLAVQQEVTP QLRRKICEVV AEVARNLIDE 120
  121 DCNNQWPDIL QFLFQCANSP TPQLQESALR IFSSVPSIFG NQEAQYIDLI KQMLAKSMDA 180
  181 GSDPEVRVQA VRAVGAFILY HDKENETAIH KHFADMLPRM IHITGETIEA QDDQSLLKLL 240
  241 IEMTENCPKF LRPQLEFIFE VCMKVFSSQD FEDSWRHLVL EVMVSLAENA PSMIRKRADK 300
  301 YIVALIPLIL HMMTDLDDDE NWSTADVVDD DDHSDNNVIA ESSLDRLACG LGGKIVLPLV 360
  361 MNALPVMLGH ADWKHRFAAL MAISAIGEGC HKQMEAILDE VMSGVLNFLS DPHPRVRYAA 420
  421 CNAIGQMSTD FAQTFEKKFH SQVIPGLLSL LDDVENPRVQ AHAGAALVNF SEDCPKNILT 480
  481 RYLDGIMAKL ETILNSKFKE LVEKGNKLVL EQVVTTIASV ADTCESEFVA YYDRLMPCLK 540
  541 FIIQNANSDD LRMLRGKTIE CVSLIGLAVG REKFIGDAGE VMDMLLVNHT EGGELADDDP 600
  601 QTSYLITAWA RMCKILGKQF EQYLPLVMGP VMRTATMKPE VAMLDNDEVE DIDGDVDWSF 660
  661 INLGEQQNFA IRTAGMDDKA SACEMLVCYA RELKEGFAEY AEDVVRQMLP MLKFYFHDGV 720
  721 RTAAAESLPY LLDCAKIKGP QYLEGMWMFI CPELLKVIVT EPEPDVQSEL LNSLAKCIET 780
  781 LGPNCLNEDA MKQVLEIINK YVLEHFERAD KRLAARNEED Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.69897
Match: 2ot8A
Description: No description for 2ot8A was found.

Predicted Domain #2
Region A:
Residues: [822-1105]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDGVEEELAE QDDTDVYILS KIVDITHALF QTNKAQFLPA FEQVAPHFVK LLEPSRPVAD  60
   61 RQWGLCVFDD LIEFCGPACA PYQQIFTPAL VQYVCDKAPE VRQAAAYGCG VLGQFAGEQF 120
  121 AHTCAQIIPL LVQVINDPKA REIENISPTE NAISAFAKIL KYNNSALSNV DELIGVWFSW 180
  181 LPVSEDSEEA AHIYGYLCDL IEGNHPVILG ANNGNLPRIV SIIAESFCTK VVEAQSATGT 240
  241 RMLTIVKQVE SNPEVMAACA STLSPEQQQA LQDAYRELAN VAPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.522879
Match: 1wa5B
Description: Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
nuclear export signal receptor activity 2.13470398426489 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
RNA binding 1.20550543134698 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
nucleic acid binding 1.00841167631924 bayes_pls_golite062009
signal transducer activity 0.662662274021266 bayes_pls_golite062009
molecular transducer activity 0.662662274021266 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
structural molecule activity 0.449804281824548 bayes_pls_golite062009
transcription regulator activity 0.385452858197632 bayes_pls_golite062009
mRNA binding 0.37278269424461 bayes_pls_golite062009
DNA binding 0.309260217284589 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle