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View Structure Prediction Details

Protein: TfIIEbeta-PA
Organism: Drosophila melanogaster
Length: 292 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TfIIEbeta-PA.

Description E-value Query
Range
Subject
Range
T2EB_BOVIN - General transcription factor IIE subunit 2 OS=Bos taurus GN=GTF2E2 PE=2 SV=1
352.0 [0..1] [286..1]
gi|73979353 - gi|73979353|ref|XP_532814.2| PREDICTED: similar to Transcription initiation factor IIE beta subunit ...
351.0 [0..1] [286..122]
gi|109086076 - gi|109086076|ref|XP_001083643.1| PREDICTED: general transcription factor IIE, polypeptide 2, beta 34...
349.0 [0..1] [286..1]
gi|228298 - gi|228298|prf||1802387B transcription factor IIE:SUBUNIT=small 34kD
347.0 [0..1] [286..1]
gi|61366471, gi|... - gi|61366471|gb|AAX42864.1| general transcription factor IIE polypeptide 2 beta [synthetic construct]...
347.0 [0..1] [286..1]
gi|34878722, gi|... - gi|34878722|ref|XP_224929.2| PREDICTED: similar to Transcription initiation factor IIE beta subunit ...
346.0 [0..1] [286..1]
T2EB_MOUSE - General transcription factor IIE subunit 2 OS=Mus musculus GN=Gtf2e2 PE=1 SV=2
345.0 [0..1] [286..1]
gi|62858005, gi|... - gi|89271975|emb|CAJ82261.1| general transcription factor IIE, polypeptide 2, beta [Xenopus tropicali...
345.0 [0..1] [286..1]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPALLRERE AFKKRAMATP TVEKKSKPDR PAPPPPSDDS RRKMRPPNAP RLDATTYKTM  60
   61 SGSSQYRFGV LAKIVKFMRT RHQDGDDHPL TIDEILDETN QLDIGQSVKN WLASEALHNN 120
  121 PKVEASPCGT KFSFKPVYKI KDGKTLMRLL KQH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.69897
Match: 1d8jA
Description: The central core domain of TFIIE beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.67074370996647 bayes_pls_golite062009
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 4.84466441605416 bayes_pls_golite062009
nucleic acid binding 4.57954522145536 bayes_pls_golite062009
transcription factor activity 4.12685284895733 bayes_pls_golite062009
binding 3.33026160538031 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
sequence-specific DNA binding 2.3918869755162 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
DNA-directed RNA polymerase activity 1.82365519759474 bayes_pls_golite062009
RNA polymerase activity 1.82365519759474 bayes_pls_golite062009
transcription elongation regulator activity 1.81270943531115 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
protein binding 0.653872239015235 bayes_pls_golite062009
nucleotidyltransferase activity 0.237727660028553 bayes_pls_golite062009
positive transcription elongation factor activity 0.13524243942225 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.0360186926687502 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [154-292]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLKGLGGILL DDVQESLPHC EKVLKNRSAE ILFVVRPIDK KKILFYNDRT ANFSVDDEFQ  60
   61 KLWRSATVDA MDDAKIDEYL EKQGIRSMQD HGLKKAIPKR KKAANKKRQF KKPRDNEHLA 120
  121 DVLEVYEDNT LTLKGVNPT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle