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View Structure Prediction Details

Protein: Dll-PA
Organism: Drosophila melanogaster
Length: 327 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dll-PA.

Description E-value Query
Range
Subject
Range
gi|786328 - gi|786328|gb|AAB32671.1| Pax-6 [Rattus sp.]
gi|480038, gi|446399 - gi|480038|pir||S36166 paired box transcription factor Pax-6 - rat (fragment), gi|446399|prf||1911405...
135.0 [0..21] [211..25]

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Predicted Domain #1
Region A:
Residues: [1-104]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAPDAPHTP KYMDGGNTAA SVTPGINIPG KSAFVELQQH AAAGYGGIRS TYQHFGPQGG  60
   61 QDSGFPSPRS ALGYPFPPMH QNSYSGYHLG SYAPPCASPP KDDF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [105-194]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SISDKCEDSG LRVNGKGKKM RKPRTIYSSL QLQQLNRRFQ RTQYLALPER AELAASLGLT  60
   61 QTQVKIWFQN RRSKYKKMMK AAQGPGTNSG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.30103
Match: 1b8iA
Description: Ultrabithorax (ubx) homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.82910876106939 bayes_pls_golite062009
DNA binding 2.71139715874068 bayes_pls_golite062009
binding 2.59102816487173 bayes_pls_golite062009
nucleic acid binding 2.4041998404334 bayes_pls_golite062009
transcription factor activity 2.30605638403993 bayes_pls_golite062009
sequence-specific DNA binding 1.81835017168096 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.77114246571754 bayes_pls_golite062009
protein binding 0.853351196918381 bayes_pls_golite062009
transcription activator activity 0.81440394306575 bayes_pls_golite062009
transcription repressor activity 0.77814500281111 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.57338514991304 bayes_pls_golite062009
transcription factor binding 0.22865859991459 bayes_pls_golite062009
chromatin binding 0.203837749053719 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [195-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLGGGGPNP GQHSPNQMHS GGNNGGGSNS GSPSHYLPPG HSPTPSSTPV SELSPEFPPT  60
   61 GLSPPTQAPW DQKPHWIDHK PPPQMTPQPP HPAATLHPQT HHHNPPPQMG GYVPQYWYQP 120
  121 ETNPSLVTVW PAV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.09
Match: 2j63A
Description: No description for 2j63A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle