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View Structure Prediction Details

Protein: FBpp0310595, FBp...
Organism: Drosophila melanogaster
Length: 914 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0310595, FBp....

Description E-value Query
Range
Subject
Range
FBpp0310590 - type=protein; loc=2R:join(19553144..19553410,19553474..19553558,19559499..19559611,19561809..1956186...
519.0 [0..1] [914..1]

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Predicted Domain #1
Region A:
Residues: [1-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCSPSTLPP APSAGQTGER GSLPLDASEK DESRLFCIKL RRSRLRRCSC GGVTLQPPSD  60
   61 GNGSTAGDNL CGQVLLNPLQ TKSEADYEKL STGKKDSIVT VAALGNFTHS VVRRATGSTG 120
  121 TSGTSSSGGN SRPGHRKSSL ALALTPEDEP MDVYQRNLMD LKYPTVLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.39794
Match: 2c2aA
Description: Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [169-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNPPLKALLV FHKSDSICEA ITAACQRHQL DVTLVKSKEE ALDTLQKSYA TAQCYHLIII  60
   61 DARSSKNLDA EHIARTIRHT HGHHLTTIIA VCKKSFFEKD DVLIALLDAG VNRCVAETTN 120
  121 LAMCSVELKQ ILHSIIRPHN VMSTQQALYT ALHRLKEVVL ITDDLLRIQY ANRATERLLN 180
  181 MRLDEIISKQ LEDIFVSDLS TISEQCKNIK EFDGILTVRR KSQEGIPMHV RVVPVACIGS 240
  241 APTHLIFNFD VPGGQMDFIA TLPQPKEAPR GSLHSVRRCS FDVRSIASDG LRRTSLAKLT 300
  301 SLPLEAPITK IINLLSQVQE NCSADEARLI DKVLEFLKRE GLYSPQMKEI RTDDPIATDL 360
  361 IGALLTGPSV YSSRRSSNDS IIRTGSSTRT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1w25A
Description: Response regulator PleD in complex with c-diGMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclase activity 4.55850369589467 bayes_pls_golite062009
phosphorus-oxygen lyase activity 4.19521126196013 bayes_pls_golite062009
adenylate cyclase activity 3.61776354332136 bayes_pls_golite062009
signal transducer activity 3.46067036099687 bayes_pls_golite062009
molecular transducer activity 3.46067036099687 bayes_pls_golite062009
guanylate cyclase activity 2.52478538563626 bayes_pls_golite062009
DNA binding 2.40455942568472 bayes_pls_golite062009
nucleic acid binding 2.27397473548288 bayes_pls_golite062009
transcription factor activity 1.64787246557234 bayes_pls_golite062009
binding 0.617577664267326 bayes_pls_golite062009
receptor activity 0.577093218389645 bayes_pls_golite062009
transmembrane receptor activity 0.200362612626285 bayes_pls_golite062009
transcription regulator activity 0.0422335506479401 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [559-914]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAIVPAKMKS NPIIMELLDE SLSWDFDIFK LEEITDYHPL LYLGMEMFRR FDVFATLNID  60
   61 ENVCKAWLAV IEAHYRKSNT YHNSTHAADV MQATGAFITQ LTNKDMLVMD RMEEATALIA 120
  121 AAAHDVDHPG RSSAFLCNSN DALAVLYNDL TVLENHHAAI TFKLTLGDDK INIFKNLDKE 180
  181 TYKSARSTII DMILATEMTR HFEHLAKFVS VFGGEEPRDH NPQTDEETSI LMRRMLIKVA 240
  241 DVSNPARPMQ FCIEWARRIA EEYFMQTDEE KQRHLPIVMP MFDRATCSIP KSQIGFIEYI 300
  301 IQDMMHAWES FIDMPQLITY MQINYSQWKK YDEQGVNTLA EIMAKQPPVG KMANSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 103.0
Match: 1oynA
Description: Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3',5'-cyclic-nucleotide phosphodiesterase activity 4.72905094107626 bayes_pls_golite062009
cyclic-nucleotide phosphodiesterase activity 4.61245226349897 bayes_pls_golite062009
phosphoric diester hydrolase activity 3.65984874547256 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 3.3591603098704 bayes_pls_golite062009
3',5'-cyclic-GMP phosphodiesterase activity 2.96981753811593 bayes_pls_golite062009
hydrolase activity 1.22736412056595 bayes_pls_golite062009
catalytic activity 1.07048165010262 bayes_pls_golite062009
binding 0.994379083280533 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.511207383357891 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.432240759268351 bayes_pls_golite062009
protein binding 0.162314119157812 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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