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View Structure Prediction Details

Protein: botv-PA
Organism: Drosophila melanogaster
Length: 972 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for botv-PA.

Description E-value Query
Range
Subject
Range
gi|54637267|gb|E... - GA13499-PA [Drosophila pseudoobscura], GA13499 [Drosophila pseudoobscura pseudoobscura]
gi|125812032, gi... - gi|54637267|gb|EAL26670.1| GA13499 [Drosophila pseudoobscura pseudoobscura], gi|125812032|ref|XP_001...
1104.0 [0..1] [972..1]

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Predicted Domain #1
Region A:
Residues: [1-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPAYDLGHS GEAYQPLDTG SGGGNEACAP NSSSAQIRHS MGFRTSWMRQ FRRYKLPMVL  60
   61 LMLLFLVSCL AYRILSVEQD APPLDLHRSS PLLDAYEDFS AMRAGDLKMR IEEMVRIKST 120
  121 VSVELRELES RRQKLQSDIS QYNQKIEELK QELLREQTEL ERLKISVEQA QVAQREAVQR 180
  181 NTPDLALPRS LLPNTLPRKS NPITGGMAA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.39794
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #2
Region A:
Residues: [210-354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SCEMHNCFNH SRCSLTSGFP VYLYDPDEHS VQRKGYDIDG FLKTTLKQTL GYNAHIVKDP  60
   61 KHACIYLVLV GEALLEQDLL RNNRYAAQEA EHQQPSTPTL ENDCPVDMEK LYSLPYWGGD 120
  121 GRNHVLLNLA RRDLTSHRTN PLYRQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [355-608]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTMRAIVVQS AFEREQFRPG YDLIVPPILG PPGGDVWQEC AEMVPARRKY LLTYQGELRP  60
   61 KQSSLNPLDA FILEHLADMA KGATQDQFVL QFQCVPATEQ QEGDSLPDWT LCGSDSSRRQ 120
  121 LLKDSTFSLI LPPLNGRVSS TLMLARIYEA LRSGAVPVIL GADELRLPYA ETVDWRRTAL 180
  181 LLPKARITEL HFLLRAVQDA DLLLLRRQGR LIWERYLSSV QATVDTVIAS LRDRLGIPPR 240
  241 PVPSVIAQSV FNST

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.07
Match: 2nzwA
Description: No description for 2nzwA was found.

Predicted Domain #4
Region A:
Residues: [609-694]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIPLKSDPPV GLDTEPEESL GPIEPPYPSP AFRRNYTILR MQAKEAWNDW LDPFYLYPQL  60
   61 PFDPALPSEA KFMGSHTGFR PIGKGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [695-972]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGAGKEFGES LGGNYPREQF TIVMLTYERE QVLMDSLGRL YGLPYLHKVV VVWNSPKPPL  60
   61 DDLRWPDIGV PVAVLRAPRN SLNNRFLPFD VIETEAVLSV DDDAHLRHDE ILFGFRVWRE 120
  121 HRDRVVGFPG RYHAWDLGNP NGQWHYNSNY SCELSMVLTG AAFVHKYYLY LYTYHLPQAI 180
  181 RDKVDEYMNC EDIAMNFLVS HITRKPPVKV TSRWTFRCPG CPVSLSEDDT HFQERHKCIN 240
  241 FFSRVFGYTP LLNTQYRADS ILFKTRIPHD KQKCFKYI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.045757
Match: 1omxA
Description: Alpha-1,4-N-acetylhexosaminyltransferase (Alpha-GalNAcT EXTL2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transferase activity, transferring hexosyl groups 4.49413422196176 bayes_pls_golite062009
UDP-glycosyltransferase activity 4.08451171179562 bayes_pls_golite062009
glucuronosyltransferase activity 4.02728111834164 bayes_pls_golite062009
heparan sulfate N-acetylglucosaminyltransferase activity 3.99063852016951 bayes_pls_golite062009
acetylgalactosaminyltransferase activity 3.4614674054855 bayes_pls_golite062009
polypeptide N-acetylgalactosaminyltransferase activity 3.19923094610567 bayes_pls_golite062009
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity 3.19489360002767 bayes_pls_golite062009
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity 2.76301940238613 bayes_pls_golite062009
mannosyltransferase activity 2.61384249067286 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.60650378115696 bayes_pls_golite062009
catalytic activity 1.88676710996045 bayes_pls_golite062009
transferase activity 1.47184463413038 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.15057449386373 bayes_pls_golite062009
cytidylyltransferase activity 1.14240569193314 bayes_pls_golite062009
nucleotidyltransferase activity 1.03393419806381 bayes_pls_golite062009
glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity 0.999230163117909 bayes_pls_golite062009
protein binding 0.967722609820275 bayes_pls_golite062009
alpha-1,2-mannosyltransferase activity 0.82476668382543 bayes_pls_golite062009
binding 0.667238976803188 bayes_pls_golite062009
UDP-N-acetylglucosamine diphosphorylase activity 0.513376694534047 bayes_pls_golite062009
uridylyltransferase activity 0.321928989676507 bayes_pls_golite062009
mannose-phosphate guanylyltransferase activity 0.2363835251362 bayes_pls_golite062009
UDP-galactosyltransferase activity 0.10185872015123 bayes_pls_golite062009
galactosyltransferase activity 0.0931461042017721 bayes_pls_golite062009
acetylglucosaminyltransferase activity 0.0562130308868509 bayes_pls_golite062009
guanylyltransferase activity 0.0539392112504681 bayes_pls_golite062009
intramolecular oxidoreductase activity 0.0122078907283503 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle