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View Structure Prediction Details

Protein: stau-PA
Organism: Drosophila melanogaster
Length: 1026 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for stau-PA.

Description E-value Query
Range
Subject
Range
tr|V9HW54|V9HW54... - Epididymis luminal protein 123 OS=Homo sapiens GN=HEL-123 PE=2 SV=1
gi|134950, gi|15... - gi|158506|gb|AAA73062.1| [D.melanogaster mRNA, complete cds.], gene product, sp|P25159|STAU_DROME Ma...
573.0 [0..1] [1026..1]

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Predicted Domain #1
Region A:
Residues: [1-228]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQHNVHAARP APHIRAAHHH SHSHAHMHLH PGMEQHLGPS LQQQQQPPPP PQQPPHRDLH  60
   61 ARLNHHHLHA QQQQQQQTSS NQAGAVAAAG AAYHHGNINS NSGSNISSNS NQMQKIRQQH 120
  121 QHLSSSNGLL GNQPPGPPPQ AFNPLAGNPA ALAYNQLPPH PPHHMAAHLG SYAAPPPHYY 180
  181 MSQAKPAKYN HYGSNANSNS GSNNSNSNYA PKAILQNTYR NQKVVVPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.09691
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [229-305]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVQEVTPVPE PPVTTNNATT NSTSNSTVIA SEPVTQEDTS QKPETRQEPA SADDHVSTGN  60
   61 IDATGALSNE DTSSSGR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [306-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGKDKTPMCL VNELARYNKI THQYRLTEER GPAHCKTFTV TLMLGDEEYS ADGFKIKKAQ  60
   61 HLAASKAIEE TMYKHPPPKI RRSEEGGPMR THITPTVELN ALAMKLGQRT FYLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.09691
Match: 1x49A
Description: Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.98844454241303 bayes_pls_golite062009
binding 2.86619976447436 bayes_pls_golite062009
structural constituent of ribosome 2.82435487029184 bayes_pls_golite062009
structural molecule activity 2.66201477910663 bayes_pls_golite062009
tubulin binding 2.64441327259575 bayes_pls_golite062009
microtubule binding 2.56910114599273 bayes_pls_golite062009
protein binding 2.48364477869915 bayes_pls_golite062009
RNA binding 1.95224155318843 bayes_pls_golite062009
DNA binding 1.49492945560218 bayes_pls_golite062009
transcription regulator activity 1.22178500811874 bayes_pls_golite062009
double-stranded RNA binding 0.967560318725736 bayes_pls_golite062009
cytoskeletal protein binding 0.935558208370217 bayes_pls_golite062009
transcription activator activity 0.880231812214114 bayes_pls_golite062009
transcription factor activity 0.31021399747574 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [420-482]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPTQIPPTDS IVPPEFAGGH LLTAPGPGMP QPPPPPAYAL RQRLGNGFVP IPSQPMHPHF  60
   61 FHG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [483-557]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGQRPFPPKF PSRFALPPPL GAHVHHGPNG PFPSVPTPPS KITLFVGKQK FVGIGRTLQQ  60
   61 AKHDAAARAL QVLKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 1o0wA
Description: RNase III endonuclease catalytic domain; RNase III, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [558-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAISASEEAL EDSMDEGDKK SPISQVHEIG IKRNMTVHFK VLREEGPAHM KNFITACIVG  60
   61 SIVTEGEGNG KKVSKKRAAE KMLVELQKLP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 1ekzA
Description: Staufen, domain III
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.98844454241303 bayes_pls_golite062009
binding 2.86619976447436 bayes_pls_golite062009
structural constituent of ribosome 2.82435487029184 bayes_pls_golite062009
structural molecule activity 2.66201477910663 bayes_pls_golite062009
tubulin binding 2.64441327259575 bayes_pls_golite062009
microtubule binding 2.56910114599273 bayes_pls_golite062009
protein binding 2.48364477869915 bayes_pls_golite062009
RNA binding 1.95224155318843 bayes_pls_golite062009
DNA binding 1.49492945560218 bayes_pls_golite062009
transcription regulator activity 1.22178500811874 bayes_pls_golite062009
double-stranded RNA binding 0.967560318725736 bayes_pls_golite062009
cytoskeletal protein binding 0.935558208370217 bayes_pls_golite062009
transcription activator activity 0.880231812214114 bayes_pls_golite062009
transcription factor activity 0.31021399747574 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [648-804]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLTPTKQTPL KRIKVKTPGK SGAAAREGSV VSGTDGPTQT GKPERRKRLN PPKDKLIDMD  60
   61 DADNPITKLI QLQQTRKEKE PIFELIAKNG NETARRREFV MEVSASGSTA RGTGNSKKLA 120
  121 KRNAAQALFE LLEAVQVTPT NETQSSEECS TSATMSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1whnA
Description: Solution structure of the dsRBD from hypothetical protein BAB26260
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.98844454241303 bayes_pls_golite062009
binding 2.86619976447436 bayes_pls_golite062009
structural constituent of ribosome 2.82435487029184 bayes_pls_golite062009
structural molecule activity 2.66201477910663 bayes_pls_golite062009
tubulin binding 2.64441327259575 bayes_pls_golite062009
microtubule binding 2.56910114599273 bayes_pls_golite062009
protein binding 2.48364477869915 bayes_pls_golite062009
RNA binding 1.95224155318843 bayes_pls_golite062009
DNA binding 1.49492945560218 bayes_pls_golite062009
transcription regulator activity 1.22178500811874 bayes_pls_golite062009
double-stranded RNA binding 0.967560318725736 bayes_pls_golite062009
cytoskeletal protein binding 0.935558208370217 bayes_pls_golite062009
transcription activator activity 0.880231812214114 bayes_pls_golite062009
transcription factor activity 0.31021399747574 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [805-1026]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTAPAVEATA EGKVPMVATP VGPMPGILIL RQNKKPAKKR DQIVIVKSNV ESKEEEANKE  60
   61 VAVAAEENSN NSANSGDSSN SSSGDSQATE AASESALNTS TGSNTSGVSS NSSNVGANTD 120
  121 GNNHAESKNN TESSSNSTSN TQSAGVHMKE QLLYLSKLLD FEVNFSDYPK GNHNEFLTIV 180
  181 TLSTHPPQIC HGVGKSSEES QNDAASNALK ILSKLGLNNA MK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.24
Match: 1qu6A
Description: dsRNA-dependent protein kinase pkr
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.80632915073735 bayes_pls_golite062009
binding 2.73737762243378 bayes_pls_golite062009
structural constituent of ribosome 2.69938614227852 bayes_pls_golite062009
tubulin binding 2.59197201719144 bayes_pls_golite062009
structural molecule activity 2.56149875079819 bayes_pls_golite062009
microtubule binding 2.50694560502594 bayes_pls_golite062009
protein binding 2.38844215549064 bayes_pls_golite062009
RNA binding 1.63984513781471 bayes_pls_golite062009
DNA binding 1.44777714653394 bayes_pls_golite062009
transcription regulator activity 1.22603137650888 bayes_pls_golite062009
cytoskeletal protein binding 0.927228352447363 bayes_pls_golite062009
transcription activator activity 0.834760842898207 bayes_pls_golite062009
double-stranded RNA binding 0.402046758389082 bayes_pls_golite062009
transcription factor activity 0.312418023287799 bayes_pls_golite062009
catalytic activity 0.00430305721638241 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle