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View Structure Prediction Details

Protein: Dg-PA
Organism: Drosophila melanogaster
Length: 997 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dg-PA.

Description E-value Query
Range
Subject
Range
gi|54636946, gi|... - gi|54636946|gb|EAL26349.1| GA14855-PA [Drosophila pseudoobscura], gi|125811155|ref|XP_001361770.1| G...
422.0 [0..25] [997..27]

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Predicted Domain #1
Region A:
Residues: [1-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFQWFLSAS ASLSLFLLLD FVVWIHGERD FNVNDSQVPV IEPKDVPAYK QDPYVTELMS  60
   61 CQNTPSEIVL SLLLKKHDWS ELTATKRAHV QAKLAKFFAI PKEFISLDSV SKRELRSMHK 120
  121 LAMRKGGKGN KNIETLNRRL GRASFMIGCG PSYFVMGEPI AKQIAHQMKD GTIGALTEEN 180
  181 F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1u2cA
Description: Crystal Structure of a-dystroglycan
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.57458227033664 bayes_pls_golite062009
cell adhesion molecule binding 1.20941485091826 bayes_pls_golite062009
protein binding 1.02797373424802 bayes_pls_golite062009
transporter activity 0.851228093937992 bayes_pls_golite062009
transmembrane transporter activity 0.677581850277121 bayes_pls_golite062009
receptor activity 0.505108400296655 bayes_pls_golite062009
substrate-specific transporter activity 0.483421965826537 bayes_pls_golite062009
signal transducer activity 0.375469021130852 bayes_pls_golite062009
molecular transducer activity 0.375469021130852 bayes_pls_golite062009
protein phosphatase binding 0.13438543889553 bayes_pls_golite062009
phosphatase binding 0.0613766967405507 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [182-334]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLWFIWRKEL KSRSNRKRRQ SEGSGADEDD YDYGDDDEEV AEPSTEVPPV TTHAHRHHHG  60
   61 APNTVLNELE LSTQLPIDDF EGTATATQPT GTATATAIAS TAAAAAATAA AATATATTAN 120
  121 ASATTAGESE FHIESTTHRT ISSKEGGEPD AIS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.08
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [335-820]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGNNSLANNE LSTPATPTSS VATTTASTPE SSSISSNFVS TDYMEPQPEE NSPPIIKTRL  60
   61 QKLAVTSGKA FTFHVLPETF YDAEDQGNLR LALTDKDGHE LKANSWLQFN ADKRELYGLP 120
  121 LDDTVSRWQY RLSATDSGNA SVTETVEISV QQHRAVRTIN HEISVFVRIN EKPGHNIDWQ 180
  181 LKLINAVART LDDSTNSAVV VREIRQTPHD PHSATFVYFN ETLPTSECPE KELKDIIARL 240
  241 DANRLSDLVQ PQLGIKSITG QLIGSCQKDL TQVKPTQHMT KNVPPMPRNQ VDRVNASLGQ 300
  301 LLVYKVPADT FYDANDNQLT LTLKTRDHLE LSPRHWLQFD SKNEEFYGIP KSGDIGSEEY 360
  361 LLVAEDSGGL SAHDALVVVV SPAPKRDFGF FFKAYLSIKH ERFNADLQRK FVERVAKLNG 420
  421 DPTTGQIQIR SITTHHDSDG TIVNFYNTTL YRKHNSCREK EVAMTRSVYL NSDLSLREAA 480
  481 KRALGP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.0
Match: 1q55A
Description: W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [821-902]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELNLTNFSVV PFSICHHTEN IDTNQLDYIP SRPEEPTHKS SFGEDYMITF VWPIVIIVAM  60
   61 LVAASIIACC LHWCRQRSGK ME

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [903-997]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGDEEERKSF RAKGIPVIFQ DEYEEKPEIG NKSPVILKDE KPPLLPPSYN TSNMNGDNDV  60
   61 DDYVPPPSVV VGGREVRGKS PATPSYRKPP PYVSP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle